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  • 1985-1989  (6)
  • Blacks (negro)  (2)
  • CR: G1.7  (2)
  • Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry  (2)
Source
Material
Years
  • 1985-1989  (6)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Correction of Numerov's eigenvalue estimates (1985)
    Springer
    Numerische Mathematik 47 (1985), S. 289-300 
    Details
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65L15 ; CR: G1.7
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary The error in the estimate of thekth eigenvalue of a regular Sturm-Liouville problem obtained by Numerov's method with mesh lengthh isO(k 6 h 4). We show that a simple correction technique of Paine, de Hoog and Anderssen reduces the error to one ofO(k 3 h 4). Numerical examples demonstrate the usefulness of this correction even for low values ofk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01389712
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Correction of finite element estimates for Sturm-Liouville eigenvalues (1986)
    Springer
    Numerische Mathematik 50 (1986), S. 205-215 
    Details
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65L15 ; CR: G1.7
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary It is shown that a simple asymptotic correction technique of Paine, de Hoog and Anderssen reduces the error in the estimate of thekth eigenvalue of a regular Sturm-Liouville problem obtained by the finite element method, with linear hat functions and mesh lengthh, fromO(k 4 h 2) toO(k h 2). The result still holds when the matrix elements are evaluated by Simpson's rule, but if the trapezoidal rule is used the error isO(k 2 h 2). Numerical results demonstrate the usefulness of the correction even for low values ofk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01390430
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A pharmacokinetic study of trifluoperazine in two ethnic populations (1988)
    Springer
    Psychopharmacology 95 (1988), S. 333-338 
    Details
    ISSN: 1432-2072
    Keywords: Trifluoperazine ; Pharmacokinetics ; Population ; Kurtosis ; Skewness ; Blacks (negro) ; Whites (caucasian)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The single dose pharmacokinetics of trifluoperazine (5 mg, Stelazine) were investigated in black (n=25) and white (n=32) healthy male subjects. Plasma samples were harvested over 24 h and analysed by a GLC-MS method. There were wide intersubject variations in all pharmacokinetic parameters examined, including C max, AUC, apparent oral volume of distribution at steady state, and elimination half-life. For each of these parameters the distribution was positively skewed in both blacks and whites and the geometric mean gave a better estimate of central tendency than the corresponding arithmetic mean. In all pharmacokinetic parameters examined there was no significant difference detected between black and white subjects or between smokers and non-smokers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181943
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Variation in the single dose pharmacokinetics of fluphenazine in psychiatric patients (1988)
    Springer
    Psychopharmacology 96 (1988), S. 206-211 
    Details
    ISSN: 1432-2072
    Keywords: Fluphenazine ; Pharmacokinetics ; Interpatient variation ; Kurtosis ; Skewness ; Blacks (negro) ; Whites (caucasian) ; Biliary recycling ; Fluphenazine conjugates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The single dose pharmacokinetics of fluphenazine (2 × 5 mg tablets, Prolixin) were studied in 21 drug free male psychiatric patients (12 black, 9 white). Plasma samples were harvested over a period of 48 h while the patients were on a strictly controlled diet. The results showed wide interpatient variations in all pharmacokinetic parameters including Cmax, AUC, apparent oral clearance, and elimination half-life. It was determined for each of these parameters that the geometric mean gave a better estimate of central tendency than the corresponding arithmetic mean and the distribution was skewed and leptokurtotic. There was no significant difference between blacks and whites in any pharmacokinetic parameter examined. Considerable variations and marked undulations in the elimination portion of the plasma concentration versus time profiles were evident, possibly indicating biliary recycling of the drug. These undulations made it difficult to determine elimination rate constants for several of the patients. Hydrolysis or plasma samples from one patient demonstrated that the conjugate(s) of fluphenazine was present in three to four times the concentration of the unchanged drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177561
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacology of octopamine-, dopamine-, and 5-hydroxytryptamine-stimulated cyclic amp accumulation in the corpus cardiacum of the american cockroach, Periplaneta americana L (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 5 (1987), S. 119-128 
    Details
    ISSN: 0739-4462
    Keywords: biogenic amine ; amine receptor ; adenylate cyclase ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: A variety of potential receptor agonists were incubated with isolated corpora cardiaca from the American cockroach Periplaneta americana to determine their effects on cyclic AMP production in this gland. Octopamine, dopamine, and 5-hydroxytryptamine elevated cyclic AMP levels in a dose-dependent manner with estimated Ka values of 15.8, 1.7, and 1.1 m̈M, respectively, and their stimulation was found to be additive. Several vertebrate receptor antagonists were tested against the three amines and a preliminary pharmacological profile developed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940050206
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacology of [3H]mianserin binding in the nerve cord of the American cockroach, Periplaneta americana (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 6 (1987), S. 191-201 
    Details
    ISSN: 0739-4462
    Keywords: [N-methyl-3H]mianserin ; cockroach nerve cord ; octopamine receptor ; cyclic AMP ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The binding of [3H]mianserin to homogenates of cockroach nerve cord was investigated, using a centrifugal binding assay. Nonspecific binding was defined as binding in the presence of 0.1 μM phentolamine. Specific binding was saturable and indicated a high affinity site (KD = 39.6 nM and Bmax = 0.8 fmol μGg-1) and a low affinity site (KD = 648.9 nM and Bmax = 5.9 fmol μg-1). The binding was reduced or abolished by heat, detergents, trypsin and HgCl2. Incorporation of CaCl2 or NaCl into the medium reduced binding in a dose-dependent fashion, whereas MgCl2 and NaF inhibited binding in a biphasic manner. The stable GTP analog, 5′-guanylylimidodiphosphate, reduced the high affinity binding at 10 μM. Phentolamine, D,L-octopamine, demethylchlordimeform (DCDM), clonidine, and D,L-synephrine are effective displacers of [3H]mianserin-binding, whereas dopamine, acetylcholine, serotonin (5-HT), and histamine show poor or no displacement. The pharmacological properties of octopamine-sensitive adenylate cyclase stimulation in cockroach nerve cord are similar to those of [3H]mianserin-binding.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940060307
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    Paper (German National Licenses)
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