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  • 1985-1989  (4)
  • Mamillary body  (2)
  • Brain areas  (1)
  • Dopamine  (1)
  • Reserpine
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 337 (1988), S. 53-57 
    ISSN: 1432-1912
    Keywords: Endogenous histamine release ; Mamillary body ; Medial amygdaloid nucleus ; Ultradian rhythm ; Suprachiasmatic nucleus ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mamillary body and the medial amygdaloid nucleus of cats anaesthetized with sodium pentobarbital were bilaterally and simultaneously superfused through push-pull cannulae with CSF and the release of endogenous histamine was determined in the superfusates. Collection of the superfusates in 10 min time periods revealed that histamine was rhythmically released in the two areas with frequencies of one cycle/90 min (mamillary body) or one cycle/135 min (medial amygdaloid nucleus). Collection of the superfusates in time periods of 2 min revealed the existence of an additional ultradian rhythm with a frequency of approximately one cycle/19 min in both areas. Bilateral lesions of the suprachiasmatic nucleus did not seem to influence the pattern of histamine release in the mamillary body and the medial amygdaloid nucleus, but the rate of histamine release was decreased in the mamillary body. It is concluded that the ultradian rhythms of histamine release in the mamillary body and the medial amygdaloid nucleus are not dependent on the integrity of the suprachiasmatic nucleus. The rate of histamine release in the mamillary body seems to be under the influence of excitatory neurons which originate from the suprachiasmatic nucleus.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 338 (1988), S. 573-576 
    ISSN: 1432-1912
    Keywords: Histamine ; Histidine decarboxylase ; Histamine-N-methyltransferase ; Brain areas ; SHR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histamine levels, histidine decarboxylase and histamine-N-methyltransferase activities were determined in various brain areas of young (9-week old) and adult (18-week old) normotensive rats (WKY) and hypertensive rats (SHR). When compared with WKY, histamine levels were increased in the anterior and posterior hypothalamus of young and adult SHR, as well as in the brainstem of young SHR. Histidine decarboxylase activity was unchanged in the posterior hypothalamus and in the medulla oblongata of young and adult SHR as well as in the anterior hypothalamus of young SHR, but it was slightly decreased in the anterior hypothalamus of adult SHR. Histidine decarboxylase activity was enhanced in the cortex-midbrain of young, as well as adult SHR, histamine-N-methyltransferase in the cortex-midbrain of young SHR. The following differences were found between young and adult rats: histamine levels were elevated in the cortex-midbrain of adult WKY and SHR. In the cortex-midbrain and brainstem of adult WKY and SHR histidine decarboxylase activity was also increased, while histamine-N-methyltransferase activity was elevated in the cortex-midbrain of adult WKY. The findings show changes in histamine levels, histidine decarboxylase and histamine-N-methyltransferase activities in SHR and suggest involvement of histaminergic neurons in hypertension. The activity of histaminergic neurons of adult rats seems to be higher than that of young animals.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 339 (1989), S. 298-301 
    ISSN: 1432-1912
    Keywords: Dopamine ; Noradrenaline ; Adrenaline ; Push-pull cannula ; Rhythmic release ; Nucleus tractus solitarii
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The release of endogenous dopamine, noradrenaline and adrenaline was studied in the nucleus tractus solitarii (subnucleus medialis) of anaesthetized cats. Two push-pull cannulae were inserted into the right and left nuclei tractus solitarii which were simultaneously superfused with artificial cerebrospinal fluid. The release of the neurotransmitters was determined in the superfusates which were continuously collected in 10 min or 2.5 min time periods for 6 h or 2 h, respectively. Collection of the superfusates in time periods of 10 min showed that the release rates of endogenous dopamine, noradrenaline and adrenaline varied rhythmically according to an ultradian rhythm, the time interval between 2 adjacent phases of high release rate being approximately 1 h. Some of the phases of high release rates of the three endogenous catecholamines timely coincided with each other. Collection of the perfusates in time periods of 2.5 min revealed the existence of additional oscillations with a frequency of about 1 cycle/10 min for dopamine, noradrenaline and adrenaline. The findings suggest that catecholamines are released in the nucleus tractus solitarii according to an ultradian rhythm with low (1 cycle per h) and high (1 cycle per 10 min) frequencies, which might reflect the activity of catecholaminergic neurons in this brain structure.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 339 (1989), S. 564-567 
    ISSN: 1432-1912
    Keywords: Histamine release ; Hypothalamus ; Amygdala ; Mamillary body ; Push-pull cannula
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anaesthetized cats, mamillary bodies, hypothalamic areas and medial amygdaloid nuclei were bilaterally superfused through push-pull cannulae and the effects of the electrical stimulation on the release of endogenous histamine were investigated. Electrical stimulation of the mamillary body increased the release of histamine in the stimulated area, as well as in the contralateral mamillary body. Electrical stimulation of the lateral hypothalamic area enhanced the histamine release in the contralateral hypothalamic area. Stimulation of the posterior hypothalamic area led to a delayed increase in the histamine release in the stimulated area. Stimulation of the medial amygdaloid nucleus reduced the release if histamine in the ipsilateral posterior hypothalamic area, while the histamine release in the contralateral lateral hypothalamic area was enhanced. The results demonstrate that electrical stimulation of distinct brain areas rich in histaminergic neurons may either increase, or decrease the release rate of histamine in the stimulated area and/or in remote brain areas.
    Type of Medium: Electronic Resource
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