ISSN:
1432-2013
Keywords:
Cardiac myocyte
;
contraction
;
sarcoplasmic reticulum
;
caged Ca
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The “caged” calcium chelator Nitr-5 was Incorporated into isolated rat ventricular myocytes. Brief illumination with ultra-violet light made the cell twitch. The light-induced twitch was inhibited by ryanodine (1–10 μM) suggesting that it resulted from calcium-induced release of calcium from the sarcoplasmic reticulum. Inhibition of the Ca current (Ni, 10 mM) abolished the electrically stimulated twitch but did not inhibit the light-induced twitch. These results provide direct evidence for the importance of Ca-induced Ca release in excitation-contraction coupling in the heart.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581820
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