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Quantitative assessment of the effect of cyproheptadine on spastic paretic gait: a preliminary study (1986)

Wainberg, M. ; Barbeau, H. ; Gauthier, S.

Springer

Journal of neurology 233 (1986), S. 311-314

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ISSN: 1432-1459

Keywords: Cyproheptadine ; Locomotion ; Spasticity ; Spinal cord injury

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The effects of cyproheptadine were studied in two patients with spastic paresis. The study consisted of two phases: a control phase (no medication) and a cproheptadine phase (8 mg t.i.d.). The effects were evaluated from electromyographic (EMG) and kinematic analysis of treadmill walking with a portion of body weight supported, and from clinical examination and subjective assessments. Episodes of spontaneous spasms and elicited clonus were reduced with cyproheptadine. Improvement in locomotor function was evidenced by a decreased cycle duration, more regular foot-floor contact, functional joint excursions, and increased walking speed. In addition, a tonic EMG activity pattern was replaced by phasic muscle activation in the proximal extensors especially. Selective proximal movements were unmasked (hip flexion) and certain functional activities (transfers, dressing) were facilitated. The results support the role of cyproheptadine as an antispastic medication. Study of the short-term and long-term benefits of cyproheptadine is continuing.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00314166

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Glass transition relations in ionomeric “comb” polymers (1986)

Wollmann, D. ; Gauthier, S. ; Eisenberg, A.

Stamford, Conn. [u.a.] : Wiley-Blackwell

Polymer Engineering and Science 26 (1986), S. 1451-1456

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ISSN: 0032-3888

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: The glass transition temperatures (Tg) and dynamic mechanical properties of random copolymers of styrene-4-vinylpyridine quaternized with iodoalkanes are presented for vinylpyridine contents up to ten percent and pendant alkyl chains up to ten carbons in length. Two linear relationships, between ion content and glass transition temperature and between pendant alkyl chain length and the Tg, are observed. An equation is presented that can be used to predict the Tg for such copolymers based on their ion contents and alkyl chain lengths.

Additional Material: 5 Ill.