ISSN:
1432-1912
Keywords:
Perfused rat kidney
;
5-Hydroxytryptamine
;
5-Hydroxytryptamine agonists
;
5-Hydroxytryptamine antagonists
;
5-Hydroxytryptamine receptors
;
Prejunctional 5-HT1-like receptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The present study has identified a receptor for 5-hydroxytryptamine (5-HT) which functions to inhibit the stimulus-induced release of [3H] noradrenaline following sympathetic periarterial nerve stimulation to the isolated perfused rat kidney. In addition to 5-HT (IC30=4.5×10−8 mol/l), both 5-carboxamidotryptamine (IC30=8×10−9 mol/l) and 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl) indole (RU-24969, IC30=2.5×10−7 mol/l) acted as agonists whereas 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) was inactive. The inhibitory effect of 5-HT on the electrically-evoked release of tritium was antagonized in a concentration-dependent manner by methiothepin (IC50=4×10−9 mol/l), metergoline (IC50=4×10−8 mol/l) and methysergide (IC50=1.3×10−7 mol/l) but not by cyproheptadine, ketanserin, mesulergine, (−)-propranolol, (±)-pindolol, (±)-cyanopindolol, metoclopramide or phentolamine. It is concluded that the receptor to 5-HT conforms to general criteria defining 5-HT1-like receptors but at the present time the receptor site cannot be fitted to the designated 5-HT1A, 5-HT1B or 5-HT1C subtypes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00633190
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