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Digitale Medien

The acute effects of intravenous nisoldipine on left ventricular function 24 to 72 hours after uncomplicated acute myocardial infarction (1988)

Nooijer, Ron C. ; Wall, Ernst E. ; Cats, Volkert Manger ; [weitere]

Springer

Cardiovascular drugs and therapy 2 (1988), S. 673-678

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ISSN: 1573-7241

Schlagwort(e): nisoldipine ; acute myocardial infarction ; left ventricular function ; radionuclide angiography ; echocar-diography

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The acute effects on left ventricular function of nisoldipine were studied in six patients 56±12 hours (range 44 to 72 hours) after the onset of uncomplicated acute myocardial infarction. Nisoldipine was administered as a 4.5 μg/kg intravenous bolus over 3 minutes followed by an infusion of 0.2 μg/kg during 60 minutes. Radionuclide angiography and two-dimensional echocardiography were performed before and during infusien with nisoldipine. The left ventricular ejection fraction increased significantly from 38%±10% to 49%±10% (P=0.028) during nisoldipine infusion. Regional wall motion index was determined both by radionuclide and by two-dimensional echocardiography and showed a significant change during nisoldipine infusion from 1.9±0.3 to 1.5±0.3 (p=0.028, radionuclide angiography) and from 0.7±0.2 to 0.3±0.2 (p=0.043, two dimensional echocardiography). Heart rate increased significantly from 78±12 min-1 to 92±13 min-1 (p=0.028), but mean double product did not change significantly during nisoldipine infusion. It is concluded that nisoldipine significantly improves global and regional left ventricular function in patients shortly after acute myocardial infarction. This beneficial effect may, however, be partially offset by an increase in heart rate. Since mean double product did not change, it is suggested that nisoldipine may improve coronary blood flow in patients with acute myocardial infarction.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00054208

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Digitale Medien

Improved detection of acute myocardial infarction by magnetic resonance imaging using Gadolinium-DTPA (1989)

Dijkman, Paul R. M. ; Doornbos, Joost ; Roos, Albert ; [weitere]

Springer

The international journal of cardiovascular imaging 5 (1989), S. 1-8

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ISSN: 1573-0743

Schlagwort(e): Magnetic Resonance Imaging ; acute myocardial infarction ; Gadolinium-DPTA ; contrast agents

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary To assess the value of the paramagnetic contrast agent Gadolinium (Gd)-DTPA in Magnetic Resonance Imaging (MRI) of acute myocardial infarction (AMI), we studied 20 patients with a first AMI by ECG-gated MRI before and after intravenous administration of 0.15mmol/kg Gd-DTPA. The MRI studies were performed after a mean of 98 hours (range 15–241) after the acute onset of AMI. Spin-echo measurements (TE 30 msec) were made using a Philips Gyroscan (0.5 Tesla). After performing the baseline MRI scans, the MRI procedure was repeated every 10 minutes for up to 40 minutes following injection of Gd-DTPA. In 18 (90%) patients contrast enhancement in the infarcted myocardial areas was observed after Gd-DTPA. In these patients intensity versus region curves, derived from 9 to 11 adjacent myocardial regions of interest, showed increased signal intensities in the infarcted areas after administration of Gd-DTPA. The precontrast signal intensity ratio between infarcted and normal myocardium was 1.14±0.15 (mean±SD); the postcontrast ratios at 10 minutes were 1.41±0.21 (P 〈0.05), at 20 minutes 1.61±0.19 (P 〈0.01), at 30 minutes 1.43±0.20 (P 〈 0.05), and at 40 minutes 1.33±0.20 (P=NS). It is concluded that MRI using the contrast agent Gd-DTPA significantly improves the visualization and detection of infarcted myocardial areas in patients with AMI and that optimal contrast enhancement is obtained 20 minutes after administration of Gd-DTPA.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01745226

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Digitale Medien

Ethylen-Polymerisation mit trägerfixierten Organometallverbindungen. IV. Über die Desaktivierung des Katalysators Tetrabenzylzirkonium-AluminiumoxidTeil III: siehe [2] (1986)

Ernst, E. ; Giesemann, J. ; Mellerowicz, Th. ; [weitere]

Weinheim : Wiley-Blackwell

Acta Polymerica 37 (1986), S. 67-70

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ISSN: 0323-7648

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Physik

Beschreibung / Inhaltsverzeichnis: Interruption of the monomer feed during the polymerization of ethylene with catalysts produced by reaction of tetrabenzylzirconium with γ-alumina shows that deactivation of the catalyst is not caused by the polyethylene being formed. Catalysts obtained from alumina with different thermal pretreatment and, therefore, different contents of hydroxyl groups on the surface show different deactivation rate.

Notizen: Unterbrechung der Monomerzufuhr bei der Ethylen-Polymerisation mit Katalysatoren, hergestellt aus Tetrabenzylzikonium und γ-Aluminiumoxid, zeigt, daß die Katalysatordesaktivierung nicht durch das gebildete Polyethylen bewirkt wird. Katalysatoren aus Aluminiumoxid mit unterschiedlicher thermischer Vorbehandlung und daher mit unterschiedlichem Gehalt an freien Hydroxylgruppen auf der Oberfläche haben unterschiedliche Desaktivierungsgeschwindigkeit.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/actp.1986.010370201

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Digitale Medien

Ethylen-Polymerisation mit trägerfixierten Organometallverbindungen. III. Konzentrationsbestimmung der aktiven Zentren des Katalysators Tetrabenzylzirkonium-AluminiumoxidTeil II: siehe [2] (1986)

Ernst, E. ; Giesemann, J. ; Ulbricht, J.

Weinheim : Wiley-Blackwell

Acta Polymerica 37 (1986), S. 28-31

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ISSN: 0323-7648

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Physik

Beschreibung / Inhaltsverzeichnis: The concentration of active sites of supported catalysts, produced by reaction of γ-alumina with tetrabenzyl zirconium was determined by quenching the polymeization of ethylene with labelled butanol. If a small amount of metal organic compound is fixed on the surface of the support, 10% of these compounds are active in polymerization, but with a surplus of metal organic compound on the surface the activity is less than 5%. These catalysts possess active centres having different rate of propagation for ethylene.

Notizen: Die Konzentration der aktiven Zentren von Trägerkatalysatoren aus γ-Aluminiumoxid und Tetrabenzylzirkonium wurde durch Abstoppen der Ethylen-Polymerisation mit tritiiertem Butanol bestimmt. Wenn nur eine geringe Menge metallorganischer Verbindung auf der Trägeroberfläche fixiert ist, sind 10% dieser Oberflächenverbindungen polymerisationsaktiv, während mit einem Überschuß von Metallorganyl auf der Oberfläche die Aktivität geringer als 5% ist. Diese Katalysatoren besitzen Zentren, die unterschiedliche Wachstumsgeschwindigkeit für Ethylene aufweisen.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/actp.1986.010370108

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