ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Cleavage of Z-Group and Formation of Hydantoine during Saponification of Z-Peptide EstersIn the course of alkaline decomposition of the tetrapeptide ester Z-Arg(NO2)-Gly-Phe-Phe-OMe one gets a high output of a by-product. the latter was isolated and identified by 13C-n.m.r. spectroscopy to be the hydantoine derivative arising from a loss of Z-group and from a cyclisation. A possibility to suppress the undesired side-reaction by addition of benzylalcohol is proposed resulting from the discussion of a probable mechanism of reaction.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19853270315
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