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  • 1985-1989  (2)
  • Choroid plexus papilloma  (1)
  • GFAP  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Immunohistochemical studies on cellular character of microtumors induced by ethylnitrosourea in the rat brain utilizing anti-leu 7 and anti-glial fibrillary acidic protein antibodies (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 167-169 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Rat ; ENU ; Brain tumor ; Anti-Leu 7 ; GFAP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To clarify the chronologic changes in the cellular morphology of ENU-induced rat brain tumors, microtumors in the early stage were examined ummunohistochemically in comparison with macrotumors in the advanced stage. The tumor cells composing microtumors were negative for glial fibrillary acidic protein (GFAP), a specific marker of astrocylic cells, and Leu 7, a marker of oligodendrocytes, while cells of macrotumors were positive for either GFAP or Leu 7, showing characteristics of mature glial cells. The results suggested that the small round cells in the early devolopmental stage, generally thought to resemble mature oligodendrocytes, are not differentiated oligodendrocytes or astrocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688694
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Choroid plexus papilloma and giant cell glioblastoma induced in hamsters with bovine adenovirus type 3 (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 218-222 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Choroid plexus papilloma ; Giant cell glioblastoma ; Bovine adenovirus type 3 ; Hamster
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Newborn hamsters were inoculated with 0.02 ml of bovine adenovirus type 3 (BAV 3) having a titer of 104.5TCID50/0.1 ml. Of 82 hamsters observed over 40 days after viral inoculation, 15 developed choroid plexus papilloma after a latency period of 41–228 days and six developed giant cell glioblastoma after a latency period of 66–214 days. Multiple foci of abnormal cell grwoth were also observed in the meninges and choroid plexus. Choroid plexus papilloma developed in the ventricles occupying the ventricular cavity and histologically showed a radiating arrangement of spindle-shaped cells forming perivascular pseudorosettes. Giant cell glioblastoma developed in the cerebral cortex including the meninges. The tumors were reddish in color and soft in consistency. Histologically, the tumor cells were short-spindle, ovar or, pleomorphic cells with a large vesicular nucleus, and were characterized by the appearance of monster cells and hypervascularity. The short spindle-shaped cells were positive for glial fibrillary acid protein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688586
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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