ISSN:
1432-0533
Keywords:
Rat
;
ENU
;
Brain tumor
;
Anti-Leu 7
;
GFAP
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To clarify the chronologic changes in the cellular morphology of ENU-induced rat brain tumors, microtumors in the early stage were examined ummunohistochemically in comparison with macrotumors in the advanced stage. The tumor cells composing microtumors were negative for glial fibrillary acidic protein (GFAP), a specific marker of astrocylic cells, and Leu 7, a marker of oligodendrocytes, while cells of macrotumors were positive for either GFAP or Leu 7, showing characteristics of mature glial cells. The results suggested that the small round cells in the early devolopmental stage, generally thought to resemble mature oligodendrocytes, are not differentiated oligodendrocytes or astrocytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00688694
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