ISSN:
1573-7284
Keywords:
Campylobacter pylori
;
In-vitro susceptibility
;
Antibiotics
;
Antiulcer drugs
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Forty-nine isolates of Campylobacter pylori were tested for their susceptibility to twenty antibiotics and four anti-ulcer agents by an agar dilution technique. Penicillin and amoxycillin were the most active drugs (MIC90, 0.06 μ/ml); erythromycin, cefazolin, minocycline, ciprofloxacin, ofloxacin and gentamicin were sligthtly less active (MIC90, ≤ 1 μg/ml). Moderate activity was found for doxycyclin, rifampin, nitrofurantoin, norfloxacin, pefloxacin, enoxacin, paromomycin, metronidazole and tinidazole. All strains were resistant to trimethoprim (MIC 〉 512 μg/ml). Nalidixic acid (MIC90, 〉 256 μg/ml) and colistin (MIC90, 〉 64 μgg/m1) had little to no activity. Of four anti-ulcer drugs, only bismuth subcitrate showed activity (MIC90, 64 μg./ml). Strains resistant to all 4-quinolones were found in patients who had previously received ofloxacin as part of a clinical trial aimed at eradication of C. pylori. These isolates remained susceptible to amoxycillin, tetracyclines and to other classes of antibiotics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00144743
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