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Digitale Medien

Mechanism of calcification: Role of collagen fibrils and collagen-phosphoprotein complexes in vitro and in vivo (1989)

Glimcher, Melvin J.

New York, NY [u.a.] : Wiley-Blackwell

The @Anatomical Record 224 (1989), S. 139-153

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Details

ISSN: 0003-276X

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin

Notizen: Samples of decalcified chicken bone together with varying concentrations of phosphoproteins from bone or egg yolk (phosvitin) were used in vitro as heterogenous nucleators for the induction of Ca-P apatite crystals. The lag time between exposure of the collagen-phosphoprotein complexes and the time nucleation of crystals occurred decreased as the concentration of Ser(P) and Thr(P) increased. Enzymatic cleavage of the phosphate groups by wheat germ and phosphatase reversed this effort, indicating that the phosphate group per se principally facilitated the nucleation of Ca-P crystals by the phosphoprotein complex and collagen.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/ar.1092240205

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