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  • 1985-1989  (2)
  • Dietary protein  (1)
  • Triglyceride  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 135-143 
    ISSN: 1432-1440
    Keywords: Serum cholesterol ; Nutrition ; Dietary protein ; Thyroxine ; Mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different dietary proteins determine different serum cholesterol levels if fed in a semisynthetic diet to some, but not all, animal species. In one species, the rabbit, this metabolic response is elicited without adding high sucrose or cholesterol supplements that have to be added to rat or pig diets in order to cause a similar response. Eleven out of 13 studies show that casein and soy protein do not induce different serum cholesterol levels in normal man. More important, protein-induced differences of serum cholesterol concentrations have not been reported when appropriate nutritional methodology has been applied. We conclude that no protein-induced hypercholesterolemia is observed in primates, particularly not in the human species. Dietary recommendations urging the general public to reduce consumption of animal protein because of a higher atherogenicity are not supported by the present data. The biochemical basis of the metabolic responses has been studied by many investigators, but no convincing unifying concept has yet been identified. The recent observation of higher serum thyroxine concentrations following soy protein consumption (and vegetable protein in general) when compared to casein shed new light on this problem. This endocrine response explains a wide array of metabolic features of soy-fed rodents: the lower hepatic VLDL secretion, the higher hepatic HMG-CoA reductase activity, the higher hepatic apo B, E receptor activity, the higher fecal bile acid excretion, and finally the lower serum cholesterol concentrations.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1436-6215
    Keywords: cholesterol ; triglycerides ; lipoproteins ; ω 3 fatty acids ; Cholesterol ; Triglyceride ; Lipoproteine ; ω-3-Fettsäuren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung In einem Kurzzeit-Experiment wurde an gesunden, normolipidämischen Probanden geprüft, ob durch einen mäßig hohen Fischverzehr der Gehalt an Plasma- und Lipoproteinlipiden gesenkt werden kann. 8 Teilnehmer aßen eine Woche lang täglich 100 g Makrele (entsprechend etwa 2,5–3 g ω-3-Fettsäuren). Die Triglycerid-Konzentrationen im Plasma und in den VLDL und LDL waren nach der Fischdiät um 40, 46,7 und 38,5 % niedriger als zu Beginn des Experiments. Die Plasmacholesterol-Konzentration war nur geringfügig erniedrigt, das Verhältnis HDL/Gesamt-Cholesterol aber signifikant erhöht. Die Studie zeigt, daß eine moderate Steigerung des Fischverzehrs bei gesunden, normolipidämischen Probanden innerhalb einer Woche — selbst auf der Basis einer nicht strikt kontrollierten Diät — die Lipidspiegel verändern kann.
    Notes: Summary The effect of mackerel consumption on plasma and lipoprotein lipid concentrations was studied in a seven-day experiment in eight healthy, normolipidemic subjects. Participants ate about 100 g mackerel (corresponding to about 2.5–3 g ω3 fatty acids daily. The mean triglyceride concentrations in total plasma, VLDL, and LDL were significantly reduced by 40, 46.7, and 38.5 % respectively after fish consumption. There was also a small (non-significant) reduction of plasma cholesterol and a (significant) increase of the ratio of HDL/total plasma cholesterol. These data show that a moderately increased intake of ω-3 fatty acids by fish food can change lipid characteristics in healthy normolipidemic individuals within a short-time period, even on a free diet.
    Type of Medium: Electronic Resource
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