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  • 1985-1989  (3)
  • Dopamine  (2)
  • LY163502  (2)
  • Polymer and Materials Science  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Effects of D2-dopaminergic receptor stimulation on male rat sexual behavior (1987)
    Springer
    Journal of neural transmission 68 (1987), S. 153-170 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine ; sexual behavior ; LY163502 ; autoreceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of selective D2-dopaminergic receptor stimulation with LY163502 on male rat copulatory behavior were evaluated. LY163502 (25 ng/kg to 25Μg/kg s. c.) produced increases in the percentage of sexually inactive rats displaying mounting behavior and ejaculating during the test period. Within this same dose range, LY163502 administration induced an increase in the percentage of non-ejaculator rats that were capable of ejaculation. These findings are viewed as evidence that LY163502 can initiate sexual behavior and lower the threshold for ejaculation. The effects of LY163502 were further evaluated in rats that were capable of ejaculation during the test period. LY163502 (25 ng/kg to 25Μg/kg s. c. or p. o.) induced significant reductions in ejaculatory latency. These effects were blocked by prior treatment with centrally active dopaminergic antagonists, RO 22-1319 and sulpiride, but not with a peripherally active antagonist, domperidone. LY163502 administration was also found to inhibit sexual behavior in low doses of 25 pg/kg −10 ng/kg s. c. and in a much larger dose of 25 mg/kg s. c. These inhibitory effects are viewed as behavioral manifestations of selective dopaminergic autoreceptor activation with low doses and as the disruption of sexual behavior by induction of intense stereotypic behavior with high doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02098495
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of D2-dopaminergic receptor stimulation on the lordotic response of female rats (1987)
    Springer
    Psychopharmacology 91 (1987), S. 96-100 
    Details
    ISSN: 1432-2072
    Keywords: Lordotic behavior ; Dopamine ; D2 receptors ; LY163502 ; Autoreceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of LY163502, a highly selective D2 dopaminergic agonist, on the lordotic response of ovariectomized, estrogen-treated rats were evaluated. LY163502, administered subcutaneously or orally, produced a significantly greater lordotic response than vehicle. LY175877 [the opposite (+) enantiomer] was found to be inactive. The effects of subcutaneous administered LY163502 were abolished by prior treatment with dopaminergic receptor antagonists such as haloperidol orcis-flupenthixol. These studies are supportive of the view that LY163502 can initiate and potentiate female sexual behavior by stimulating D2 type dopaminergic receptors. In contrast to the enhancement of lordotic response that was observed in nonreceptive female rats, LY163502 was found to have suppressive effects on lordotic response frequency of receptive (estrogen-progesterone-treated) female rats. Reductions in lordotic responding occurred in two dose ranges, above and below the dose range found to potentiate lordotic response. The maximal suppressive effect at the low dose range was observed at 250 pg/kg, SC. This reduction in lordotic responding was proposed to be associated with a selective dopaminergic autoreceptor activation, leading to a diminished dopamine release and expression of a dopamine-mediated behavior (i.e., lordotic response). The reduction of lordotic responding that was observed at higher doses (25 μg/kg-25 mg/kg) was associated with an induction of stereotypic behavior that may have disrupted the sexual response pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690934
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal properties of rigid polymers. I. Measurement of thermal conductivity and questions concerning contact resistanceThis work is drawn in part from the thesis of John A. Hall, submitted in partial fulfillment of the Master of Science degree requirements of the University of Maine at Orono. (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 33 (1987), S. 2029-2039 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Several studies of the influence of contact resistance on the measurement of thermal conductivity of polystyrene using a steady-state device are presented. In each case it is seen that, although this influence can perhaps be minimized, it cannot be eliminated as an experimental complication. A novel technique is then described which does eliminate entirely contact resistance as a variable, and this technique is shown to yield an unequivocal value of thermal conductivity.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1987.070330615
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    Paper (German National Licenses)
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