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  • 1985-1989  (2)
  • Epoxide hydrolase  (1)
  • Mouse  (1)
  • Kalte Konservierung
  • Olfactory blockade
  • 1
    Electronic Resource
    Electronic Resource
    Reactions of olfactory bulb neurons to different stimulus intensities in laboratory mice (1986)
    Springer
    Experimental brain research 63 (1986), S. 151-157 
    Details
    ISSN: 1432-1106
    Keywords: Olfactory bulb ; Single units ; Odor concentration ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activity of 219 cells in the olfactory bulb of waking, freely breathing mice was analysed, and it was found that their spontaneous discharge rate varied between 0.3 and 33 AP/s. Both butyric acid and geraniol elicited responses of four types: 38% of the 98 responses were of type 1 (excitation), 43% of type 2 (inhibition), 10% of type 3 (complex structure), and 8% were characterized by a change in the temporal pattern of the activity. Response duration varied from less than 500 ms to more than 1 min. 52 secondary neurons were stimulated with four different concentrations of the odor substances. All of the responsive cells showed a clear ability to discriminate concentration. That is, response magnitude varied with intensity, producing non-monotonie curves. Most of the neurons responded only in a region of a more or less limited concentration, and in no case was a saturation curve observed. Approx. 40% of the neurons responded to the lowest concentration tested (10−8 vol. % of butyric acid or geraniol). The strongest stimuli, 10−2 vol.%, were relatively ineffective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235657
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Species differences in the formation of butadiene monoxide from 1,3-butadiene (1985)
    Springer
    Archives of toxicology 57 (1985), S. 222-225 
    Details
    ISSN: 1432-0738
    Keywords: Rodents ; Human ; Epoxidation ; Epoxide hydrolase ; 1,3-Butadiene ; Butadiene monoxide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When 1,3-butadiene is incubated with liver postmitochondrial fractions from mouse, rat, monkey or man and a NADPH-regenerating system, the formation rate of butadiene monoxide is different in the four species. With the exception of the rhesus monkey, the amount of epoxide is proportional to the monooxygenase activity. The sequence of epoxide formation is B6C3F1 mouse, Sprague Dawley rat, man, rhesus monkey. The ratio between mouse and monkey was about 7∶1. When 1,3-butadiene is incubated with homogenates from lung tissue, only tissues from mouse and rat produce measurable butadiene monoxide concentrations. The monooxygenase activity in lung tissue of the mouse was only 1/30 that in mouse liver. By contrast, lung tissue formed epoxide concentrations comparable to those formed by liver tissue, whereas monkey and human lung tissue did not produce any measurable levels of butadiene monoxide. The data might suggest that the results of recent rodent inhalation studies with 1,3-butadiene could not automatically be extrapolated to man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00324781
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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