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  • 1985-1989  (2)
  • Hip dysplasia  (1)
  • Presynaptic α1-α2-adrenoceptors  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Possible involvement of presynaptic α1-adrenoceptors in the effects of idazoxan and prazosin on 3H-noradrenaline release from tail arteries of SHR (1986)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 333 (1986), S. 354-361 
    Details
    ISSN: 1432-1912
    Keywords: Presynaptic α1-α2-adrenoceptors ; Idazoxan ; SHR tail arteries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of several α-adrenoceptor antagonists have been examined on tritium release elicited by electrical stimulation from isolated perfused SHR tail artery preparations prelabelled with 3H-noradrenaline (3H-NA). Phentolamine and yohimbine potently facilitated the stimulation evoked release of tritium at low frequencies of stimulation, but the α2-adrenoceptor antagonist idazoxan was only weakly active at 1 μmol/l, despite antagonising the clonidine-evoked inhibition of 3H-release at a lower concentration of 0.1 μmol/l. The α1-adrenoceptor antagonists prazosin and corynanthine also increased stimulation evoked tritium release in this preparation, suggesting the presence of prejunctional α1-adrenoceptors. Furthermore, the α1-adrenoceptor agonist methoxamine (3 μmol/l) caused a significant inhibition of tritium-evoked release, an effect which was blocked by prazosin (10 nmol/l). When α1-adrenoceptors were blocked in the presence of prazosin, idazoxan (0.1 μmol/l) produced a significant facilitatory effect on the electrically-evoked release of 3H-transmitter. On the other hand, when α2-adrenoceptors were blocked in the presence of yohimbine, exposure to idazoxan (0.1 μmol/l) reduced significantly the stimulation-evoked release of tritium elicited by electrical stimulation. The results indicate that in the SHR tail arteries, idazoxan has a partial agonist inhibitory activity on transmitter release, which can mask the facilitatory effects due to blockade of presynaptic α2-adrenoceptors. The inhibitory effects of idazoxan appear to involve presynaptic α2-adrenoceptors, which when stimulated, reduce 3H-NA release in SHR tail arteries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500009
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The anatomy of the dysplastic hip in cerebral palsy related to prognosis and treatment (1985)
    Springer
    International orthopaedics 9 (1985), S. 105-110 
    Details
    ISSN: 1432-5195
    Keywords: Cerebral palsy ; Hip dysplasia ; Prognosis ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'évolution de la dysplasie de hanche chez l'infirme moteur cérébral est étudiée à partir de 292 cas. Cette étude permet de préciser la vitesse de migration de la hanche, ce qui autorise à formuler très tôt dans l'évolution dysplasique un pronostic anatomique. L'analyse des signes radiologiques précoces de la dysplasie en fonction de l'autonomie locomotrice de l'enfant dégage un remarquable parallélisme anatomofonctionnel. Ainsi, l'analyse des premières images radiographiques permet tout à la fois une prévision anatomique et une prévision fonctionnelle, autorisant un traitement précoce et adapté aux futures conditions de vie de l'enfant. Ce traitement doit être étiologique, basé sur les libérations musculo-tendineuses. Il est surtout efficace sur le recentrage coxofémoral et cela d'autant plus qu'il est réalisé plus précocément. Ces ténotomies sont au contraire peu efficaces sur la dysplasie osseuse, notamment sur l'obliquité cotyloödienne. Or, celle-ci débute vers 30 mois. Mieux vaut donc prévenir sa survenue par des ténotomies précoces et toujours bien tolérées plutôt que de la corriger par ostéotomie pelvienne, moins bien supportée par ces enfants fragiles.
    Notes: Summary The development of dysplasia of the hip in cerebral palsy has been studied in 292 hips in children. The rate of migration of the hip has been defined, and gave a very early indication of the prognosis for the dysplasia. A close relationship was also found between the early radiographic changes and the functional locomotor anatomy. By reviewing the initial radiographs the need for early treatment and its adaptation to the future locomotor potential of the child can be assessed. Treatment is usually by musculotendinous releases and is especially effective in early recentring of the femoral head, but this method is ineffective in correcting bone dysplasia, particularly acetabular obliquity, which starts at around the age of 30 months. It is preferable to anticipate its development by early tenotomies which are much better tolerated than pelvic osteotomy in spastic children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266951
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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