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Additive positive inotropic effects of milrinone, ouabain and calcium in diseased human ventricular myocardium (1986)

Brown, L. ; Näbauer, M. ; Erdmann, E.

Springer

Journal of molecular medicine 64 (1986), S. 708-712

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ISSN: 1432-1440

Keywords: Milrinone ; Ouabain ; Positive inotropic effect ; Myocardium

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The interactions of milrinone, ouabain and calcium on force of contraction in isolated, contracting human papillary muscle strips were measured. Milrinone (EC50, 8 × 10−5 M) increased force of contraction maximally by 2.8±0.8 mN at 5 × 10−4M; significantly less than either ouabain (1 × 10−7M; 4.8±0.5 mN increase) or calcium (15 mM; 6.2±0.6 mN increase). A submaximal, but not a maximal, inotropic effect of ouabain could be increased by the addition of milrinone; in contrast, both ouabain and calcium increased the maximal inotropic effect of milrinone by 1.7±0.2 mN and 2.7±0.3 mN, respectively. The combined inotropic effect of milrinone with either ouabain of 4.2±0.3 mN or calcium of 5.6±0.4 mN was not different from that with calcium or ouabain alone. We conclude that further positive inotropic effects should be expected when digitalis is given to patients with congestive heart failure who are already optimally treated with milrinone.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01712056

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In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields (1987)

Edelman, E. R. ; Brown, L. ; Taylor, J. ; [et al.]

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 21 (1987), S. 339-353

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ISSN: 0021-9304

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: The kinetics of drug release from polymerdrug matrices containing an embedded magnet was continuously monitored in vitro and in vivo. The application of an oscillating magnetic field increased the rate of drug release from the polymer matrices. Within the limits of detection the increase in release occurred immediately, remained stable for as long as the field was applied, and returned exactly to baseline upon withdrawal of the field. The increase in release was directly proportional to field amplitude. The same pattern of results were observed in vivo as in vitro, though higher strength fields were required in vivo to achieve the same effect observed in vitro.

Additional Material: 9 Ill.