ISSN:
1432-2013
Keywords:
Cultured central neurones
;
ATP-sensitive
;
Patch-clamp
;
Ion channels
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract ATP-sensitive channels were observed in isolated inside-out membrane patches from rat cultured central neurones. Two types of ATP-sensitive K+ channels were present in cortical neurones, one which had its open-state probability increased, the other its open-state probability decreased by application of ATP to the cytoplasmic membrane surface. Another, ATP-sensitive channel differing in ion conductance from all previously reported ATP-sensitive channels was also seen in patches from cortical neurones. This channel was noselective with respect to Na+, K+ and Cl− ions and ATP produced a “flickery” type of block. The non-hydrolysable analogue, AMPPNP, did not mimic ATP and prevented ATP action Preliminary experiments indicate that similar, but not, identical ATP-sensitive channels exist in cerebellar neurones
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00582512
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