ISSN:
1432-0738
Keywords:
Lead
;
Thiamine
;
Ascorbic acid
;
Chelation
;
α-Mercapto-β-(2-furyl) acrylic acid
;
2,3-Dimercaptosuccinic acid
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The influence of the administration of thiamin (vitamin B1), ascorbic acid (vitamin C) or their combination on the efficacy of two thiol metal chelators, viz. α-mercapto-β-(2-furyl) acrylic acid (MFA) and 2,3-dimercaptosuccinic acid (DMS), in counteracting lead (Pb) toxicity was investigated in rats. Ascorbic acid or its combination with thiamine enhanced the urinary elimination of Pb, reduced the hepatic and renal burden of Pb, and reversed the Pb-induced inhibition of the activity of blood 5-aminolevulinic acid dehydratase (δ-ALA-D). All these effects were more evident in DMS- than in MFA-treated rats. The combination of MFA and DMS treatments further improved the performance of the animals in enhancing urinary Pb excretion and in reducing Pb hepatic levels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00332491
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