ISSN:
0749-1581
Keywords:
13C NMR
;
Tautomerism
;
Inotropism
;
Imidazopyridine
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A detailed analysis of the 13C NMR spectra of the 1-N- and 3-N-methyl derivatives of 1H-2-(2,4-dimethoxyphenyl)imidazo[4,5-c]pyridine, utilizing long-range couplings and 2D 1H—13C correlation experiments, has led to an unambiguous assignment of all carbons. Comparison of these definitive assignments of C-3a and C-7a, in particular, with those of the tautomers of 1H-2-(2,4-dimethoxyphenyl)imidazo[4,5-c]pyridine has permitted confirmation of the predominance of the 1H-tautomer for the latter. In addition, previous conflicting assignments for 1H-imidazo[4,5-c]pyridine and its 3-N-methyl derivative are now resolved. Revision of these assignments leads to the conclusion that the 1H-tautomer of 1H-imidazo[4,5-c]pyridine is predominant.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260271016
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