ISSN:
1573-4943
Keywords:
acetylcholine receptor
;
toxin-binding regions
;
synthetic peptides
;
cobratoxin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Eighteen consecutive uniform overlapping synthetic peptides that spanned the entire extracellular part (residues 1–210) of the α-chain ofTorpedo californica acetylcholine receptor were screened for binding activity of125I-labeled cobratoxin. Five toxin-binding regions were localized within residues 1–10, 32–41, 100–115, 122–150, and 182–198. The five toxin-binding regions may be distinct sites or, alternatively, different faces in one or more sites.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02343335
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