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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 389-393 
    ISSN: 1432-1041
    Keywords: ornidazole ; haemodialysis ; pharmacokinetics ; renal function ; metabolism ; urine concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of ornidazole was studied in 6 patients treated by haemodialysis and in 8 subjects with a creatinine clearance between 4 and 99 ml/min × 1.73 m2. Blood and urine collections were performed for 72 h after i.v. and oral administration of 1.0 g ornidazole. Total body clearance, half-life, volume of distribution and systemic availability were independent of renal function and did not differ from previously reported values in normal volunteers. The haemodialysis clearance of ornidazole was 〉100% higher than the total body clearance. The renal clearance of ornidazole accounted for less than 7% of the total body clearance. The percentage of the dose of ornidazole recovered in urine as parent compound or as the biologically active metabolites [α-(chloromethyl)-2 hydroxymethyl-5 nitroimidazole-1 ethanol and 3-(2 methyl-5 nitroimidazole-1-yl)1,2 propanediol] decreased linearly with decreasing renal function. Although the sum of those three compounds recovered in urine accounted for less than 10% of the total dose of ornidazole administered, they yielded therapeutic concentrations (〉4 µg/ml) in urine over 24 h after dosing. Due to the peculiar pharmacokinetic behaviour of ornidazole, i.e. high haemodialysis clearance in the absence of significant renal clearance, no dosage adjustment is necessary while renal function declines, but an increased dose is mandatory while patients are on dialysis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 29 (1986), S. 697-701 
    ISSN: 1432-1041
    Keywords: tenoxicam ; renal insufficiency ; non-steroidal antiinflammatory agents ; protein binding ; metabolism ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of tenoxicam after a single oral dose of 20 mg has been studied in 12 patients with various degrees of decreased renal function. Unchanged tenoxicam and its 5′OH-metabolite in plasma and urine were determined by HPLC. The mean areas under the plasma concentration-time curve (138±53 µg/ml·h) and terminal half-lives in patients with impaired renal function did not differ from values previously reported in normal volunteers, nor did the peak concentration of tenoxicam. The half-life of 5′OH-tenoxicam and unchanged tenoxicam where the same. The urinary excretion of 5′OH-tenoxicam fell with decreasing renal function. Thus no dosage adjustment should be necessary and the usual daily dose of tenoxicam may be administered once daily also to patients with renal failure.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Euphytica 36 (1987), S. 121-127 
    ISSN: 1573-5060
    Keywords: Avena sativa ; oats ; grain yield ; yield response ; yield stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Relationships that exist among grain yielding ability and response and stability of grain yields when tested over variable environments were examined. Two sets of oats lines were tested over many environments that had wide ranges in productivities. The lines in each set were divided into high-, medium-, and low-yielding groups on the basis of means across all environments, and variance components for genotype × environment interactions and means of regression responses and coefficients of determination were computed for the three yield categories in each set. Mean grain yields for the high-, medium-, and low-yielding groups across both sets of oats lines were 2.7, 2.3, and 1.9 Mg ha-1, respectively. Coefficients of variability for the genotype × environment interaction were 18%, 16%, and 12% for the high-, medium-, and low-yielding categories, respectively. Means for regression responses were 1.22 for the high group, 0.99 for the medium, and 0.78 for the low. Most responses for the high and low groups were significantly different from 1.0. Means for coefficients of contingency were 0.63, 0.56, and 0.51 for the high-, medium-, and lowyielding groups, respectively. There was a positive relationship between mean grain yield and response of grain yield to improving environments. Thus, high yielding lines are also the responsive lines. Our study gave conflicting results about stability of production for the three yield groups. Coefficients of variation for genotype × environment interaction indicated that the high-yielding group was more interactive with environments than were the medium- and low-yielding ones: However, the means for coefficients of contingency indicated that the high yielding group was the most stable.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Euphytica 34 (1985), S. 21-31 
    ISSN: 1573-5060
    Keywords: Avena sativa ; oats ; phenotypic correlations ; transgressive segregation ; protein yield ; grain yield
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Relationships among the traits protein percentage, grain yield, and protein yield of oats were studied with F2-derived lines in F3 and F4 from 27 matings obtained by crossing high-protein with high-yield oat lines. High-protein parents were (a) selections from an Avena sativa bulk, (b) selections from three-way matings in which an initial parent was A. sterilss, and (c) cultivars. High-yield parents were derived from backcross populations involving A. sterilis accessions as donor parents. Significnnt genetic variation existed among F2-derived lines for grain and protein yield in all matings and for protein percentage in all but one mating. Protein percentage had a highly significant negative correlation with grain yield (r=−0.33**) when pooled over all matings, but in five, these two traits were not correlated. Overall, protein percentage showed a small negative correlation with protein yield (r=−0.09*), and protein and grain yields had a high positive association (r=0.98**). F2-derived lines with both high protein percentage and high grain yield were obtained. High transgressive segregates for protein percentage occurred in two matings, for grain yield in nine, and for protein yield in 14. Most high transgressive segregates for protein yield were high because of high grain yield only, but in four matings, lines were found where protein yield was increased by concurrent increases in both protein percentage and grain yield. Only a few specific parental combinations between high-protein and high-yield parents produced segregates in which increased protein percentage contributed materially to high-protein yields.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-5060
    Keywords: Pennisetum glaucum ; pearl millet ; factor analysis ; morphological traits ; physiological traits ; grain yield ; yield determinants ; pleiotropy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The plant breeder's task of improving and stabilizing many plant traits simultaneously is complicated by interrelationships that occur among the traits. Factor analyses were conducted on three phenotypically diverse pearl millet [Pennisetum glaucum (L.) R. Br.] composites to describe the structure of relationships among yield, morphological, and physiological traits. Approximately 1000 S0 spaced-plants from each composite were evaluated for 20 traits, and random samples of 289 S1 progenies from each composite were evaluated for 18 of these traits. Factors extracted in S0 and S1 populations identified unique sets of traits that were interrelated along axes of (a) biological yield, (b) panicle size, (c) dry matter partitioning and (d) compensation between number and size of seeds. Several plant traits had large loading coefficients on the ‘Biological Yield’ and also, but with opposite signs, on the ‘Dry Matter Partitioning’ factor. The traits having large loading on these two factors differed between space-planted and normal-density stands, showing that environmental conditions contributed to the associations observed among traits. Correlations of S1 with parental S0 factor scores for the ‘Biological Yield’, ‘Panicle Size’ and ‘Seed Paramters’ factors produced significant correlation coefficients, indicating that these trait complexes had a genetic basis. The implications of these results for millet breeding are discussed.
    Type of Medium: Electronic Resource
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