ISSN:
1573-8221
Schlagwort(e):
muscular dystrophy
;
cyclic AMP
;
lysosomes
;
acid phosphatase
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract After denervation and in avitaminosis E the cyclic AMP level, falls in rabbit muscle tissue but activity of cyclic AMP phosphodiesterase rises. In experiments in vitro cyclic AMP, in a concentration of 10−4M inhibits the liberation of acid phosphatase from the lysosomerich fraction isolated from the muscles of rabbits with avitaminosis E. In muscular dystrophy, the increase in acid hydrolase activity in the skeletal muscle may thus be due to liberation of enzymes from the lysosomes, as a result of labilization of their membranes through a fall in cyclic AMP concentration.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00799467
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