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Digitale Medien

Reflections on notochordal differentiation arising from a study of chordomas (1985)

HEATON, J. M. ; TURNER, D. R.

Oxford, UK : Blackwell Publishing Ltd

Histopathology 9 (1985), S. 0

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ISSN: 1365-2559

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: This study of thirteen cases of chordoma serves to emphasize the occurrence of three different histological patterns; classical, seven; chondroid, three; and intermediate or mesenchymal, three. The study also suggests that more adequate sampling of these tumours detects the chondroid variant more readily. These varying patterns of differentiation in tumours of notochordal origin suggest that the parent tissue may have the potential to develop along similar lines in the embryo. Thus mesenchymal and cartilaginous tissue formed from notochordal cells could contribute to the formation of the nucleus pulposus and inner portion of the intervertebral disc cartilages. This concept contrasts with the previously held view that the notochord atrophies at an early stage in embryonic development.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2559.1985.tb02835.x

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Digitale Medien

Chronic serum sickness glomerulonephritis: Passive immunisation inhibits the removal of glomerular antigen and electron dense deposits (1988)

Furness, P. N. ; Turner, D. R.

Springer

Virchows Archiv 413 (1988), S. 551-553

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ISSN: 1432-2307

Schlagwort(e): Glomerulonephritis ; Chronic serum sickness ; Immune complexes ; Passive immunisation

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Chronic serum sickness glomerulonephritis was induced in 20 Wistar rats, using radio-labelled, chemically cationised bovine serum albumin (BSA) as antigen. Four days after the last injection of antigen, when relocation of antigen within the rat had effectively ceased, the rats were given a single large intraperitoneal dose of either non-immune rat gamma globulin or anti-BSA rat gamma globulin. Ten days later the rats were killed. The rats which had received the anti-BSA globulin had significantly more antigen in renal cortex and in isolated glomeruli than the control group. They also had larger mesangial deposits as assessed by morphometry at electron microscope level; assessment of subepithelial deposits provided equivocal results. These findings provide direct confirmation that circulating antibody which is directed against an antigen which is trapped within deposits in the glomerulus will inhibit the removal of the antigen and deposits from the mesangium.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00750396

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Digitale Medien

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations (1985)

Turner, D. R. ; Morley, A. A. ; Haliandros, Marina ; [weitere]

[s.l.] : Nature Publishing Group

Nature 315 (1985), S. 343-345

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Mutant HPRT" cells can be selected for by the purine analogue 6-thioguanine (TG) as described previously1'3. Lymphocytes obtained from the blood of healthy adult males were cloned at limiting dilution either in the absence of TG (unselec-ted, presumably HPRT+ clones) or in the presence of 2.5 g ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/315343a0

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