ISSN:
0749-1581
Keywords:
Queuine
;
Hypermodified purine
;
Structure and conformation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The hypermodified nucleotidyl purine queuine [7-(3,4-trans-4,5-cis-dihydroxycyclopent-1-en-3-ylaminomethyl)-7-deazaguanine] is a substrate for transfer ribonucleic acid (tRNA) enzymes replacing guanine at nucleotide position 34 of tRNAs for the amino acids aspartic acid, asparagine, bistidine and tyrosine. The structure and conformation of native queuine was studied by one-dimensional 13C and 1H NMR spectroscopy and by two-dimensional NMR spectroscopy (COSY and NOESY). The structure in solution was found to be the 3,4-trans-4,5-cis-dihydroxycyclopent-1-ene form. The plane of the cyclopentene ring is probably perpendicular to that of the purine ring structure.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260260103
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