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Residual effect of single and repeated doses of midazolam and nitrazepam in relation to their plasma concentrations (1986)

Godtlibsen, O. B. ; Jerkø, D. ; Gordeladze, J. O. ; [et al.]

Springer

European journal of clinical pharmacology 29 (1986), S. 595-600

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ISSN: 1432-1041

Keywords: midazolam ; nitrazepam ; psychomotor performance ; residual plasma drug level ; carry over effect

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Twelve healthy volunteers were given either midazolam 15 mg or nitrazepam 5 mg for 7 consecutive days in a randomized cross-over trial. Self-assessment of sleep, mood or condition on awakening and adverse effects was performed, and the volunteers underwent evaluation of psychomotor performance. Hypnotic effect, judged by the classical sleep variables, showed that the drugs were more or less equal and were superior to placebo. Nitrazepam consistently produced an impaired condition on awakening and also clearly displayed a spectrum of adverse motor effects. Motor tests revealed impairment induced by both drugs, but, in the midazolam group the effect subsided during the trial period. Both drugs had a significant effect on memory, midazolam appearing to perturb certain memory functions to a greater extent than did nitrazepam. The residual plasma concentration of midazolam 11 h after treatment correlated well with the scores obtained in several of the psychomotor tests, whereas plasma nitrazepam levels were not related to performance in any subtest. When discontinued neither drugs, induced any rebound phenomenon. However, the adverse effects of nitrazepam appeared to be carried over into the adjacent placebo period.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00635899

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Simultaneous determination of glyceryl trinitrate and its metabolites in plasma using capillary gas chromatography with on-column injection (1986)

Langseth-Manrique, K. ; Bredesen, J. E. ; Greibrokk, T.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 9 (1986), S. 643-647

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ISSN: 0935-6304

Keywords: Capillary gas chromatography (CGC) ; Simultaneous quantitation ; Human plasma ; Glyceryl trinitrate ; Glyceryl dinitrate ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A specific, sensitive, and precise assay for simultaneous quantitation of glyceryl trinitrate (GTN) and its metabolites 1,2-and 1,3-glyceryl dinitrate (GDN) has been developed. The method involves one single extraction step with benzene, followed by evaporation at 55°C. One μl of the extract was injected onto a capillary fused silica column with trifluoropropyl as the stationary phase. The column separated all the nitrates within 17 minutes using temperature programming from 90 to 155°C. The lower limits of detection were 0.05, 0.5, and 0.1 nmol/I for GTN, 1,2-GDN and 1,3-GDN respectively. The calibration curves were linear in the concentration ranges 0.05-10.0 nmol/I (GTN), 0.5-10.0 nmol/I (1,2-GDN) and 0.1-10.0 nmol/I (1,3-GDN). Plasma concentration data from two patients receiving intravenous GTN infusion are presented.

Additional Material: 2 Ill.