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  • 1985-1989  (3)
  • 1
    Digitale Medien
    Digitale Medien
    Thymic nurse cells: division of thymocytes within complexes (1989)
    Springer
    Cell & tissue research 258 (1989), S. 637-643 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Thymic nurse cells ; Thymic cell complexes ; Thymocytes ; Autoradiography ; Mouse (BDF1)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Thymic nurse cell complexes (TNC-c), isolated from mouse thymuses at 1 and 2 h after i.v. injection of 6-(3H)thymidine, were analyzed in autoradiographs of semithin serial sections with regard to their size and the distribution of labeled thymocytes in individual types of complexes. The total number of thymocytes per complex reflects the type of complex. In a parallel study, localization of labeled thymocytes within individual zones of thymic cortex was examined. Thymocyte division within complexes may yield sequential complex generations differing in number per complex. However, thymocytes within complexes differ from each other in division kinetics. Half of the thymocytes that had been labeled 1 h after injection divided within 2 h. The rapidly dividing fraction of thymocytes were distributed within small complexes containing 2–8 cells and corresponded to the distribution of labeled cells in the outer thymic cortex. The proportion of labeled cells within large complexes resembled the distribution of labeled cells in the deep cortex. The data support the view that microenvironmental factors within TNC-c are responsible for both inducing thymocytes to enter the cell cycle and the negative selection (cell death) of some thymocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00218877
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Multicellular complexes of thymocytes and different types of thymic stromal cells in the mouse (1986)
    Springer
    Cell & tissue research 244 (1986), S. 673-679 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Thymic cell complexes ; Nonlymphoid thymic cells ; Thymus ; Mouse
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The isolation of multicellular complexes of thymocytes and different types of thymic stromal cells from the mouse thymus is described. Isolated complexes were examined by light microscopy. Stromal cells, binding thymocytes at their surface, were identified using electron microscopy, and three types of epithelial cells, macrophages and interdigitating-like cells (IDC-like cells) were distinguished from their morphological characteristics. The epithelial cell types correspond morphologically to epithelial cells present in situ in various thymic regions. The type of thymocyte-contact with epithelial cells, macrophages and IDC-like cells indicated that the formation of multicellular complexes is common.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00212548
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Distribution of different cell types within the rat thymus in the neonatal period of life (1985)
    Springer
    Cell & tissue research 240 (1985), S. 473-478 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Thymus ; Non-lymphoid cells ; Cell contacts ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary This study attempted to define reciprocal positions of cell types within the thymus. Random or non-random contacts between specific cell types were analyzed by means of graph theory. For analysis, thymus blocks were sectioned serially and, then, thymus cells were categorized into types, based on morphological criteria. The distribution of individual cell types within the cortex, cortico-medullary zone and medulla was presented in form of a map. In the analysis, three types of epithelial cell, characteristic of each thymus zone, macrophages, Langerhans-like cells and lymphocytes were found in non-random relations to one another. Moreover, characteristic groups of cells associated with one another were also demonstrated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00222362
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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