ISSN:
1432-0428
Schlagwort(e):
Type 2 (non-insulin-dependent) diabetes
;
kidney function
;
glomerular filtration rate
;
kidney volume
;
urinary albumin excretion
;
newly diagnosed diabetes
;
glycaemic control
;
HbA1c
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Glomerular filtration rate, kidney volume, and urinary albumin excretion rate were studied in otherwise healthy newly diagnosed Type 2 (non-insulin-dependent) diabetic patients, untreated at diagnosis, after short-term treatment and after 3 months treatment. In 10 patients (Group A) glomerular filtration rate (measured by the plasma clearance of 51-Cr-EDTA) decreased from the time of diagnosis 106.2±14.6 ml·min−1·1.73m2−1 (mean±SD) to 95.9±13.7 ml·min−1·1.73m2−1 after 3 months treatment (p=0.049). At the same time, mean plasma glucose was reduced from 13.3±3.2 mmol/l to 6.5±1.1 mmol/l. The fall in mean plasma glucose was correlated to the reduction in glomerular filtration rate, r=0.76, p=0.011. Kidney volume as measured by ultrasonic scanning was reduced from 264.0±33.7 ml/l.73m2 to 210.8±23.8 ml/l.73 m2 (p〈0.005). The relative decline in urinary albumin excretion rate was correlated to the fall in glomerular filtration rate, r=0.69, p=0.026. In 15 patients (Group B) 24-h urine collections were made during 9.5±3.2 days, urinary albumin excretion rate fell from the first to the last day in hospital from 14.0×/÷3.0 μg/min (geometric mean ×/÷ tolerance factor) to 7.0×/÷2.7 μg/min p=0.015. The relative decline was correlated to the change in mean plasma glucose, r=0.65, p=0.032. Thus, kidney function in Type 2 diabetic patients is influenced by metabolic control, although to a lesser extent than is seen in Type 1 (insulin-dependent) diabetic patients with comparable glycaemic control. Urinary albumin excretion is reduced by improvement in glycaemic control, to which it is significantly correlated. Long-term consequences of reduction in urinary albumin excretion on the development of diabetic nephropathy and on survival remains to be elucidated.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00271263
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