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  • 1985-1989  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Progress in Model Studies of Cellular Uptake (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 446 (1985), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1985.tb18406.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and plasma protein binding of two platinum cytostatics CHIP and CBDCA in rats (1986)
    Springer
    Cancer chemotherapy and pharmacology 17 (1986), S. 133-136 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma protein binding and pharmacokinetic parameters of CHIP (cis-dichloro-trans-dihydroxy-bisisopropylamine platinum IV) and CBDCA (cis-diammine-1,1-cyclobutane dicarboxylate platinum II) were investigated in male Wistar rats. The plasma clearance of total and non-protein-bound platinum was determined and compared with that of 99mTc-DTPA. for binding experiments, a novel, simple, and quick method based on adsorption of non-protein-bound platinum species to charcoal was used. The clearance of total platinum after CHIP and CBDCA administration was markedly lower than the glomerular filtration rate (determined as the clearance of 99mTc-DTPA). The renal clearance of non-proteinbound platinum corresponded to 168% and 50% of the glomerular filtration rate for CHIP and CBDCA, respectively. These studies suggested that CHIP was excreted by the rat kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306741
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence ofcis-dichlorodiamineplatinum on glioma cell morphology and cell cycle kinetics in tissue culture (1987)
    Springer
    Journal of molecular histology 19 (1987), S. 187-194 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary C6 glioma cells (CCL 107) were cultured for three days and then treated withcis-dichlorodiamineplatinum (cis-DDP) at doses of 0.2–10 µg/ml medium. Changes in DNA synthesis and DNA content, as well as morphology of cells and chromatin distribution, were examined from the first post-treatment day onwards. The number of cells labelled with [3H]thymidine, detected autoradiographically, decreased after treatment with 0.2–10 µg/ml by approximately one half on post-treatment day 1 and diminished further by the third day after treatment. The labelled cells were entirely absent only after treatment with 10µg/ml, 7 days post-treatment. Mitoses decreased from 1.4–0.6% by post-treatment day 1 and completely disappeared by day 3 (1 µg/ml). Feulgen cytophotometry and propidium iodide cytofluorimetry revealed accumulation of cells in the S-phase, especially the latter part (0.5 and 1.0 µg/ml, post-treatment day 1) and subsequently also in G2 phase (post-treatment day 3). Incomplete cyto- and karyokinesis in some cycling cells was indicated by an increased number of binucleate cells and nuclei of higher ploidy classes. Labelled cells with intermediate DNA values were, on average, labelled less intensively, as was revealed by simultaneous measurements of DNA content and [3H]thymidine incorporation. Some cells displayed reduction in grain density over heterochromatin clumps. This would be in agreement with the late S-phase block of DNA replication. After post-treatment day 3 the density of cells in cultures was substantially lower. This was due to slowed transversing through the cell cycle and cell death occurring after post-treatment day 1 with higher doses or after day 2 with lower doses (up to 1 µg/ml). The size of the nuclei of surviving cells enlarged initially (post-treatment day 1) and later (day 7) giant cells with long, branched fibres similar to those of reactive astrocytes occurred. Texture analysis of Feulgen-stained nuclei revealed that the chromatin of cells treated withcis-DDP became less evenly distributed. This might be due either to the direct influence ofcis-DDP on the DNA molecule, or mediated by changes in cytoskeleton and cAMP levels described earlier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01680628
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Correlation between the sequence-length distribution and structure of statistical copolymers of L-valine and γ-benzyl-L-glutamate (1987)
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. 705-725 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Statistical copolymers were prepared from N-carboxyanhydrides of L-valine and γ-benzyl-L-glutamate in dioxan with triethylamine as an initiator. The copolymerization conversion was determined by ir spectroscopy, the copolymer composition by amino acid analysis, and the molecular weights by light scattering. The monomer reactivity ratios were found to be rVal = 0.14 and rGlu(OBzl) = 6.4. High-molecular-weight copolymers are formed even at low conversions. The content of β-structure in the copolymers was estimated from the ir spectra in copolymerization mixtures. The sequence-length distribution of L-valine and γ-benzyl-L-glutamate copolymers was calculated and its dependence on copolymerization conversion is discussed. Relations between the sequence-length distribution and the content of β-structure were studied. It was found that the content of β-structure in samples with the same composition is different for low- and high-conversion copolymers. The formation of β-structure in copolymers in the copolymerization mixture requires a certain minimal sequence length, which has been found to be about 6 valine units.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360260511
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Polyglutamines-versatile biodegradable carriers (1985)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 9 (1985), S. 129-135 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Biodegradation of homopolymers, poly-α-[Nγ-(2-hydroxyethyl)-L-glutamine] and poly-α-[Nγ-(2-hydroxypropyl)-L-glutamine], and of copolymers, poly-α-[Nγ-(2-hydroxyethyl)-L-glutamine-co-L-phenylalanine] with 3.7, 5.6, and 10.2 mol-% of Phe units was studied in vitro using pronase E, chymotrypsin A4 and extracts from native tissues. Gel permeation chromatography was used for evaluating the molecular-weight distribution of the original and partially degraded polymers. Homopolymers of Nγ-(2-hydroxyalkyl)-L-glutamines are biodegradable in the main chain by pronase as well as by native tissue extracts, yielding low-molecular-weight products. Although chymotrypsin does not catalyze hydrolysis of peptide bonds in the homopolymers, incorporation of phenylalanine units in the main chain by copolymerization renders the copolymer degradable by this enzyme, most probably in phenylalanyl-glutamine bonds.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1985.020091985117
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