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  • 1
    Electronic Resource
    Electronic Resource
    8-OH-DPAT elicits gnawing, and eating of solid but not liquid foods (1987)
    Springer
    Psychopharmacology 92 (1987), S. 192-195 
    Details
    ISSN: 1432-2072
    Keywords: 8-OH-DPAT ; Solid food ; Glucose solution ; Gnawing ; Eating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioural specificity of the eating elicited by the serotonergic agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) was investigated. In non-deprived rats 8-OH-DPAT (60–240 μg/kg) increased the consumption of solid food pellets. The consumption of an 18% glucose solution was unaffected by 60 μg/kg 8-OH-DPAT, and markedly reduced by 120 μg/kg 8-OH-DPAT. When rats were pre-fed glucose, to reduce glucose intake under control conditions, 60 μg/kg 8-OH-DPAT significantly decreased subsequent glucose consumption. The failure of 8-OH-DPAT to induce a hyperphagic response to glucose suggests that this compound does not elicit eating by an action upon feeding motivation. Observational analyses showed that 8-OH-DPAT-treated rats exhibited several oro-facial motor responses, including gnawing, which were attenuated by pretreatment with haloperidol. It is likely, therefore, that the increase in solid food intake elicited by 8-OH-DPAT is incidental to drug-induced gnawing. Possible mechanisms of this action are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177914
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The anorectic action of peripheral 5-HT examined in the runway: evidence for an action on satiation (1987)
    Springer
    Psychopharmacology 93 (1987), S. 498-501 
    Details
    ISSN: 1432-2072
    Keywords: Peripheral 5-HT ; Feeding ; Satiation ; Runway behaviour ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hypothesis that systemically administered 5-hydroxytryptamine (5-HT) reduces feeding by a specific action on satiation and satiety processes was examined using a food-rewarded runway task. Over the course of 15 successive trials, with food available for 2 min on each trial, the development of satiation was monitored following treatment with 5-HT (1 and 2 mg/kg SC) and saline. The 5-HT failed to alter runway performance over the early trials, but then induced marked decrements in running speed and food intake. Analysis of cumulative food intake curves showed that 5-HT significantly reduced food intake beginning at the point where a decline in the rate of feeding was observed under control conditions. These results indicate that 5-HT exerts its anorectic effect only after some food has been ingested, and support the hypothesis that 5-HT accelerates the development of satiation and satiety.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207242
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Enhancement of 5-HT-induced anorexia: a test of the reversibility of monoamine oxidase inhibitors (1989)
    Springer
    Psychopharmacology 98 (1989), S. 265-268 
    Details
    ISSN: 1432-2072
    Keywords: Clorgyline ; Reversible MAO inhibitors ; 5-HT ; Sucrose intake ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Subcutaneous injection of 1 mg/kg 5-hydroxytryptamine (5-HT) reduced the intake of a 10% sucrose solution in rats. A single injection of the monoamine oxidase inhibitor (MAOI) clorgyline enhanced the anorectic effect of 5-HT. Such an effect persists 2, 24, 48, 72 and 96 h after injection. The clorgyline treatment almost completely inhibited type A MAO activity in the liver at 2 h post-injection. By 120 h, the time at which potentiation of 5-HT induced anorexia disappeared, MAO-A activity had returned to 80% of control values. These results demonstrate that the clorgyline effect is long-lasting and irreversible. Brofaromine (5 mg/kg) and cimoxatone (20 mg/kg) also enhanced the anorectic effect of 5-HT injected 2 h later. The potentiating effects of brofaromine and cimoxatone were not observed when 5-HT was administered 24 h later. These results indicate that brofaromine and cimoxatone are short-acting, reversible inhibitors of MAO-A activity in vivo. Moclobemide (30 mg/kg) failed to enhance the anorectic action of 5-HT injected 2 and 24 h later. The potentiation of 5-HT induced anorexia may be a useful behavioural test for investigating the degree of reversibility, and time course of action of MAOIs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444703
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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