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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 30 (1986), S. 187-190 
    ISSN: 1432-1041
    Keywords: isosorbide dinitrate ; haemodialysis ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 10 patients with end stage renal disease on regular haemodialysis the plasma concentrations and dialyzer clearance of isosorbide dinitrate (ISDN) were determined after an oral dose of a retarded release formulation of 60 mg ISDN. The maximal plasma concentration of ISDN 2–7 h after oral administration was higher (14 ng/ml) than has been reported in healthy volunteers. The haemodialyzer clearance of ISDN was 92.4 ml/min at a blood flow of 200 ml/min and dialysate flow of 500 ml/min. During a 5-h haemodialysis an average of 0.3 mg ISDN was removed from the patient's circulation, representing about 0.5% of the administered dose and about 3% of the available drug in the circulation. No influence of haemodialysis on the plasma level of ISDN was found.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 16 (1985), S. 321-328 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Fractography of Fibre Reinforced PlasticsIf damage such as cracks of fractures occur in fibre reinforced plastic components, the fractography, that is the examination of the fracture surface, is the most important part of the failure analysis. If this investigation is done in the scanning electron microscop (SEM), it is called microfractography.Successful application of microfractography on metals has been made for more than 20 years in elucidating material failure. On the subject of microfractography on fibre reinforced plastic, basic knowledge has been worked out but is known to day only to a few specialists. This field is in development in the USA and in Western-Europe A comprehensive and definitive fracture atlas, as available for metals, is not existing.The completion of such an atlas will take about five to ten years. The US-Air Force, however, has the intention to produce a handbook „Fractography of Composite Structures“ in a shorter time.The results presented in this paper have been obtained from 1973 to 1984. Proceedings from defined fractures following static and dynamic loading the microfractography features are characterised and documented with pictures. The results are compared with those published in the literature.
    Notes: Treten an Bauteilen aus faserverstärkten Kunststoffen (z.B. CFK, GFK), Materialschäden wie Brüche, Risse usw. auf, so ist die Fraktographie, d.h. die Untersuchung der Bruchflächen, ein wesentlicher Teil der Schadensanalytik. Wird letzteres im Rasterelektronenmikroskop (REM) vorgenommen, so spricht man von Mikrofraktographie. Die Mikrofraktographie wird an Metallen seit etwa 20 Jahren erfolgreich zur Aufklärung von Materialschäden eingesetzt, so daß kaum noch Bruchuntersuchungen ohne REM durchgeführt werden.Auf dem Gebiet der Mikrofraktographie an faserverstärkten Kunststoffen sind bereits Grundkenntnisse vorhanden, allerdings lediglich bei wenigen Spezialisten. Das Wissensgebiet ist im Aufbau begriffen, was für die USA und Westeuropa gilt.Einen „endgültigen“ Bruchatlas, wie er für Metalle vorhanden ist, gibt es noch nicht. Die Fertigstellung eines solchen wird mindestens noch 5 bis 10 Jahre in Anspruch nehmen. Andererseits hat sich die „Air Force“ in den USA zur Aufgabe gesetzt ein Handbuch „Fractography of Composite Structures“ in einem kürzeren Zeitraum zu erstellen. Die in der vorliegenden Arbeit vorgestellten Ergebnisse sind im Zeitraum 1973 bis 1984 erarbeitet worden. Ausgehend von definierten Brüchen unter statischer und schwingender Beanspruchung sind die beanspruchungsspezifischen mikrofraktografischen Charakteristikas herausgearbeitet und durch Bilder dokumentiert worden. Die Ergebnisse werden mit den relativ wenigen Literaturergebnissen verglichen.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 16 (1985), S. 347-354 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 27 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 16 (1985), S. 384-391 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Zusammenfassend kann festgestellt werden, daß es gelungen ist, an einer Anzahl von Brucharten an verschiedenen faserverstärkten Verbundwerkstoffen spezifische makro- und vor allem mikrofraktographische Charakteristikas zu finden und durch rasterelektronenmikroskopische Vergleichsbilder zu dokumentieren.
    Additional Material: 28 Ill.
    Type of Medium: Electronic Resource
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