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  • 1
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a prospective randomised study in 20 insulin-dependent diabetics who had minor surgery under general anaesthesia we compared the metabolic responses to intravenous glucose-insulin-potassium infusion with those who had conventional subcutaneous insulin administration. The former treatment resulted in lower blood glucose levels both during the infusion period (p 〈 0.05) as well as the entire observation period (operative, first and second postoperative days; p 〈 0.01). More blood glucose values were within the intended range of 5 to 10 mmol/litre in the glucose-insulin-potassium as compared to the conventional group (48% versus 24%; p 〈 0.01). The levels of lactate, 3-hydroxybutyrate, glycerol, alanine, glucagon, insulin and growth hormone did not differ between the two groups. The infusion regimen resulted in better glycaemic control both peri-and postoperatively than the conventional subcutaneous insulin regimen in insulin-dependent diabetic patients who have minor surgery.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Echocardiography ; left ventricular function ; Type 1 diabetes ; metabolic control ; diabetic cardiopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cardiac function was investigated by echocardiography in 24 short-term Type 1 diabetic patients with a mean diabetes duration of 7 years (range 4–14 years) during conditions of ordinary metabolic control. Compared to 24 age and sex matched normal control subjects, measurements of myocardial contractility as left ventricular fractional shortening and mean circumferential shortening velocity were increased by 12% and 20% respectively. Another 8 Type 1 diabetic patients were examined during conditions of poor (hyperglycaemia and ketosis) and good metabolic control. Following improved glycaemic control, left ventricular fractional shortening and mean circumferential shortening velocity decreased by 16% and 24% respectively. Our findings show that short-term Type 1 diabetes is associated with increased myocardial contractility. Furthermore, this condition is related to the state of metabolic control.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; blood glucose ; artificial pancreas ; diet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The blood glucose responses to cooked potato, rice and spaghetti were studied in six Type 1 (insulin-dependent) diabetic patients who had attained euglycaemia by the artificial pancreas prior to the meal intake. The amount of potato (raw weight 200 g), parboiled rice (raw weight 50 g), and spaghetti (raw weight 50 g) had approximately identical caloric content (range 203–225 kcal) and amount of available carbohydrate (range 39.4–43.4g). The postprandial blood glucose response areas after cooked potato and cooked parboiled rice were similar (180 min values: cooked potato: 1190 ±110 mmol/l x min, cooked rice: 1160 ± 140 mmol/l x min and 240min values: cooked potato: 1690 ± 140 mmol/l x min, cooked rice: 1740 ± 210 mmol/l x min). In contrast, the response after cooked spaghetti was slower and less pronounced (180 min value: 830 ± 80 mmol/1 x min and 240 min value: 1320 ± 120 mmol/1 x min), and was significantly smaller than those of cooked potato (180 min: 2p 〈 0.01 and 240 min: 2p 〈 0.01) as well as cooked rice (180 min: 2p 〈 0.01 and 240 min: 2p 〈 0.02). Our study emphasizes the importance of determining the glycaemic response of foodstuffs under conditions of isoinsulinaemia.
    Type of Medium: Electronic Resource
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