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Activity of blood coagulation Factor XIII as a prognostic indicator in patients with Henoch-Schönlein purpura (1987)

Kamitsuji, H. ; Tani, K. ; Yasui, M. ; [et al.]

Springer

European journal of pediatrics 146 (1987), S. 519-523

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ISSN: 1432-1076

Keywords: Henoch-Schönlein purpura ; Factor XIII ; Substitution therapy ; Blood coagulation ; Allergic vasculitis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Determination of coagulation Factor XIII (F XIII)-related parameters in 21 patients with Henoch-Schönlein purpura documented a significant decrease of F XIII activity as well as of the F XIII-related antigenic determinants. Subgroup analysis with regard to the clinical symptoms showed an even further decrease of these parameters in patients with gastrointestinal complications. Stimulated by these findings a substitution therapy with a F XIII concentrate was initiated in those patients whose F XIII activity in plasma remained low and who developed severe abdominal pain accompanied by persisting gastrointestinal bleeding. This therapeutic approach not only corrected the laboratory data, but more important led to a cessation of pain and bleeding. A rapid decrease of F XIII levels after transfusion below 40 U/ml was indicative of relapse of abdominal symptoms, while increasing values were associated with the recovery of the patients. In conclusion: F XIII activity determinations appear to have a predictive value in patients with Henoch-Schönlein purpura, and the administration of F XIII concentrates may contribute to the improvement of gastrointestinal complications.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00441608

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Application of capillary gas chromatography to environmental analysis (1986)

Matsushita, H. ; Iida, Y.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 9 (1986), S. 708-711

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ISSN: 0935-6304

Keywords: Capillary gas chromatography GC-MS ; Airborne particulates ; Nitroarenes ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Routine analytical methods for benzo[a]pyrene and nitroarenes in airborne particulates are presented. Benzo[a]pyrene in airborne particulates was easily analyzed by a capillary GC/NCIMS. Analysis time was about 10 min and analytical values obtained by this method agreed well with those by HPLC/spectrofluorometry. Nineteen nitroarenes were analyzed by capillary GC/FTD following a simple clean-up procedure. Fifteen out of 19 nitroarenes analyzed were mutagenic for Salmonella typhimurium TA100 and TA98, and 4 nitroarenes were carcinogenic to experimental animals.

Additional Material: 2 Ill.