ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. The possibility that the anticonvulsant activity of the benzodiazepines, diazepam and clobazam, is related to changes in EEG parameters, particularly β activity, was investigated in amygdaloid kindled rats.2. The effects of diazepam (1, 2, 4, 8 and 16 μmol/kg), administered intraperitoneally (i.p.), clobazam (1, 2, 4, 8, 16 and 32 μmol/kg, i.p.) or vehicle (dimethyl sulfoxide) on the cortical EEG of amygdaloid kindled rats were quantitated for 15 min using computerized period amplitude analysis. Immediately afterwards, the amygdala was stimulated and the after-discharge duration (AD) and the seizures stage (SS) were determined.3. The equivalent percentage time (EPT) of the diazepam-treated group was decreased in the θ band (4–8 Hz) and increased in the α (8–12 Hz) and first six β (12–36 Hz) bands. The mean peak amplitude (MPA) was increased in the α (8–12 Hz) and all seven β bands (12–40 Hz). Clobazam increased the EPT and MPA in the α (8–12 Hz) and all seven β (12–40 Hz) bands. The MPA was also increased by clobazam in the θ (4–8 Hz) band.4. Diazepam reduced both the AD and SS of the kindled seizures at doses of 4, 8 and 16 μmol/kg, whereas clobazam was anticonvulsant at doses of 16 and 32 μmol/kg. The reduction in both AD and SS correlated with increases in the EPT and MPA in the first β (12–16 Hz) band in the diazepam-treated group and in the first four β (12–28 Hz) bands in the clobazam-treated group.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1988.tb01015.x
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