ISSN:
1573-6903
Keywords:
Vestibular
;
cholinergic
;
choline acetyltransferase
;
acetylcholinesterase
;
frog
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The amount and some properties of choline acetyltransferase (ChAT) and of acetylcholinesterase (AchE) were investigated in the frog vestibule. Enzyme activities were found to be of the same order of magnitude as in frog nervous tissue and various properties of vestibular ChAT (dependence on pH, chloride and Triton X-100 activation, phosphate sensitivity) and AchE (inhibition by eserine but not by Tetraisopropylpyrophosphoramide) were also similar as those of the homologous central nervous system enzymes. Although the precise localization of ChAT and AchE is not yet certain the efferent neurotransmitter in the vertebrate vestibular sensory periphery is believed to be acetylcholine and thus the enzymes responsible for its synthesis and degradation may participate in regulating inner ear function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00969625
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