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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 85 (1985), S. 201-203 
    ISSN: 1432-2072
    Keywords: ACTH ; Corticosterone ; Dopamine receptors ; Apomorphine ; Haloperidol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of a dopaminergic agonist, apomorphine, and a dopaminergic antagonist, haloperidol, on plasma ACTH, and corticosterone levels were evaluated in adult male rats. Subcutaneous administration of apomorphine in the dose range of 50–500 μg · kg−1 significantly increased plasma corticosterone levels. Acute treatment with apomorphine (250 μg · kg−1) resulted in an elevation of plasma ACTH concentration, peak values being reached 15 min after the injection. The apomorphine-induced rise in plasma ACTH levels was completely inhibited by pretreatment with haloperidol (1 mg · kg−1). A stimulatory role for dopamine receptors in the control of pituitary ACTH release in the rat is suggested.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2800
    Keywords: sexual behavior ; prostatic cancer ; medical castration ; orchiectomy ; antiandrogen ; LHRH agonist ; sexual desire ; intercourse ; erectile problems ; sex offenders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract The results of a written questionnaire with 44 patients (pilot study) indicated that before the beginning of treatment for advanced prostatic cancer, most subjects had an active sexual life, as illustrated by a normal erotic imagery, an adequate sexual desire and a normal frequency of intercourse. More than three-quarters (80%) of subjects had at least one coitus a week. Slightly more than 50% were able to easily achieve an erection by erotic imagery or by a preferred sexual fantasy; 50% never experienced erectile problems. When compared with their previous sexual functioning, 70% of subjects noticed during the antiandrogenic treatment a major reduction in their interest for sexual intercourse which was maintained in only 18% of patients. It became impossible for 57% to induce an erection by erotic imagery. However, 19% claimed an ability to maintain an erection during sexual activity, as compared to 56% before treatment, but erections usually lacked full rigidity. Twenty-two percent of patients mentioned having nocturnal or morning erections. Despite this dramatic decrease in sexual activity in most patients, complete antiandrogen blockade left sexual activity in approximately 20% of patients. Due to the treatment's excellent tolerance, the findings suggest that such combined androgen blockade could be beneficial for the treatment of sex offenders.
    Type of Medium: Electronic Resource
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