ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Conclusions Prostaglandin E2 may have a dual action during acute inflammation: 1. Inhibition of inflammatory mediator release, and 2. Enhancement of mediator target action, presumably by increasing local blood flow/pressure. The PGE2-sensitive enhancement of the antigen response by indomethacin suggests that endogenous vasodilating prostaglandins (possibly PGE2) predominantly were antiinflammatory. The antiallergic action of PGE2 was most likely secondary to inhibited release of inflammatory mediators from mast cells. One of these mediators was identified as histamine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02126557
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