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Haemodynamic changes during induction of anaesthesia with midazolam and diazepam (Valium) in patients undergoing coronary artery bypass surgery (1985)

KAWAR, P. ; CARSON, I. W. ; CLARKE, R. S. J. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Anaesthesia 40 (1985), S. 0

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ISSN: 1365-2044

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Midazolam 0.3 mg/kg and diazepam 0.5 mg/kg were used for induction of anaesthesia in two groups of 10 patients each undergoing coronary artery bypass surgery. Haemodynamic variables were measured during induction of anaesthesia, after pancuronium and following tracheal intubation. Haemodynamic indices were derived, from these measurements using standard formulae. The induction of anaesthesia with midazolam produced a slight but significant increase in heart rate. There was a significant fall in systemic arterial pressure and pulmonary artery pressure following both drugs. Despite the fall in systemic arterial pressure, the cardiac index was maintained in patients who received midazolam. The cardiostimulatory effect of laryngoscopy and tracheal intubation was not prevented by either of the benzodiazepines and morphine in the dosage used. Midazolam is a suitable alternative to diazepam as part of an intravenous induction regimen in patients with ischaemic heart disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2044.1985.tb11002.x

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Turbulence-producing eddies in the viscous wall region (1989)

Lyons, S. L. ; Hanratty, T. J. ; McLaughlin, J. B.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 35 (1989), S. 1962-1974

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: A computer simulation of turbulent flow in a channel is used to detect flow patterns related to the production of Reynolds stress. It is found that quadrant 2 and quadrant 4 events possess a streaky structure in the viscous wall region and that these events can be best understood by examining the velocity field in the y-z plane. Large turbulence production in the viscous wall region is found to occur in updrafts and downdrafts associated with closed eddies. These eddies, on average, have a spanwise dimension of 50 wall units and a streamwise dimension of 400-450 wall units. They are often seen to originate from small attached eddies at the wall.

Additional Material: 18 Ill.