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Groundwater Pollution and the Disposal of Hazardous and Radioactive Wastes (1989)

MATHER, J. D.

Oxford, UK : Blackwell Publishing Ltd

Water and environment journal 3 (1989), S. 0

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ISSN: 1747-6593

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Energy, Environment Protection, Nuclear Power Engineering

Notes: The demand for‘Rolls-Royce’ solutions to the disposal of hazardous and radioactive wastes has seen a continuing move towards more sophisticated disposal concepts. If a disposal site for radioactive wastes meets the strict requirements laid down by Government departments it is difficult to see why there should be any impact to groundwater of concern to the water industry. Hazardous wastes are a much more significant problem, and the large size of many landfills, other pressures on groundwater quality and current EC directives are all contributing to a move away from the use of ‘dilute and disperse’ sites. It is argued that the long-term performance of containment sites needs to be carefully evaluated over timescales of 2-3 decades, as over such periods a correctly-managed policy of ‘dilute and disperse’ may result in less of an overall impact to the environment than a policy of ‘concentrate and contain’.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1747-6593.1989.tb01364.x

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Regulation of gonadotropin receptors, gonadotropin responsiveness, and cell multiplication by somatomedin-C and insulin in cultured pig Leydig cells (1986)

Bernier, M. ; Chatelain, P. ; Mather, J. P. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Cellular Physiology 129 (1986), S. 257-263

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ISSN: 0021-9541

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: We have investigated the effects of insulin and somatomedin-C/insulinlike growth factor l(Sm-C) in purified porcine Leydig cells in vitro on gonadotrophins (hCG) receptor number, hCG responsiveness (cAMP and testosterone production), and thymidine incorporation into DNA. Leydig cells cultured in a serum-free medium containing transferrin, vitamin E, and insulin (5 μ/ml) maintained fairly constant both hCG receptors and hCG responsiveness. When they were cultured for 3 days in the same medium without insulin, there was a dramatic decline (more than 80%) in both hCG receptor number and hCG responsiveness. However the cAMP but not the testosterone response to forskolin was normal. Both insulin and Sm-C at nanomolar concentrations prevent the decline of both hCG receptors and hCG-induced cAMP production. This effect of both peptides was dose dependent with an ED50 of about 1 ng/ml and 5 ng/ml for SM-C and insulin, respectively. Insulin and Sm-C had no additive effect on these parameters. At nanomolar concentrations, Sm-C and insulin enhanced hCG-induced testosterone production but the effect of Sm-C was significantly higher than that of insulin. However, the effect of insulin at higher concentrations (5 μg/ml) was significantly higher than that of Sm-C at 50 ng/ml. In contrast, at nanomolar concentrations only Sm-C stimulated [3H]-thymidine incorporation into DNA and cell multiplication, the stimulatory effect of insulin on these parameters, was seen only at micromolar concentrations. These results indicate that both Sm-C and insulin acting through their own receptors increase Leydig cell steroidogenic responsiveness to hCG by increasing hCG receptor number and improving some step beyond cAMP formation. ln contrast, the mitogenic effects of insulin are mediated only through Sm-C receptors.

Additional Material: 6 Ill.