Electronic Resource
New York, NY
:
Wiley-Blackwell
Helvetica Chimica Acta
72 (1989), S. 1319-1323
ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The solid-phase syntheses of enkephalin and somatostatin analogues with C-terminal OH functions instead of the normal carboxylates are described. The OH function of the N-terminal amino alcohol was acylated with succinic acid and esterified to the solid support. Normal Boc-TFA solid-phase strategy can be applied to build up and cleave these peptides. The succinic ‘handle’ can be removed by mild basic hydrolysis after cleavage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19890720620
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