ISSN:
0887-624X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Conjugates of polyoxyethylene with proteins and surfaces are of much importance in various biotechnical applications. Consequently, methods for preparing the aldehyde of POE are of interest because of the potential ready attachment of this compound to proteins and aminated surfaces by reductive amination. In this work we describe the results of attempts to prepare an oligomeric POE aldehyde by six routes, two of which proved to be effective. Two previously published routes, manganese-oxide and DMSO/Ac2O oxidation were ineffective. The aldehyde was shown to be unstable in the presence of base and thus of little use for reductive amination. On the other hand, the benzaldehyde derivative, which we also synthesized, is stable, easy to prepare, and undergoes ready reductive amination.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/pola.1987.080250910
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