Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1985-1989  (9)
Source
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Correlation Between 2′,3′-Cyclic Nucleotide 3′-Phosphohydrolase Activity and Demyelination In Vitro Using a Syngeneic System (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Cultures of myelinated SJL/J fetal mouse spinal cord were incubated with serum and lymphoid cells from syngeneic animals with experimental allergic encephalomyelitis (EAE) induced by syngeneic spinal cord homogenate (SSCH) in complete Freund's adjuvant or others injected with complete Freund's adjuvant alone. After 24 or 48 h of exposure, demyelination was determined by light microscopic examination and quantification of 2′,3′-cyclic nucleotide 3′-phosphohydrolase activity. Cultures exposed to spleen or lymph node cells from SSCH-sensitized animals showed the greatest alterations in myelin and decreases in 2′,3′-cyclic nucleotide 3′-phosphohydrolase activity whereas serum from these animals had less effect. Cells and serum from complete Freund's adjuvant-injected control animals also induced structural changes in myelin that were significantly less than changes induced by cells and serum from animals with EAE. These experiments show that lymphoid cells and serum obtained from SJL/J mice with acute EAE affected myelin biochemistry and morphology in syngeneic CNS cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb05462.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Preface (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27044.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Immunoglobulin G (IgG) Localization During Acute Autoimmune Demyelination (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27084.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Tumor Necrosis Factor Mediates Myelin Damage in Organotypic Cultures of Nervous Tissue (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27175.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis (1988)
    [s.l.] : Nature Publishing Group
    Nature 331 (1988), S. 540-543 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] T-cell lines were established from two HTLV-I seronegative controls and seven TSP patients (Table 1). Purified peripheral blood lymphocytes (PEL) or cerebrospinal fluid (CSF) cells Table 1 Detection of HTLV-I associated gene products in T-cell lines derived from peripheral blood and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/331540a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Taxol-induced neuropathy: further ultrastructural studies of nerve fibre changesin situ (1985)
    Springer
    Journal of neurocytology 14 (1985), S. 157-175 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nerve fibre changes have been further monitored morphologically in rat sciatic nerves which had been locally injected with taxol, an antimitotic drug known to promote microtubule assembly. Taxol caused a slowly progressive accumulation of microtubules over a three week period of experimentation, the effect being more pronounced in Schwann cells. Schwann cells of myelinated fibres became detached from nodes of Ranvier and were applied to naked internodes as bulbous cells replete with microtubules and smooth endoplasmic reticulum (ER). In some cases, the smooth ER was believed to arise from rough ER after the displacement of ribosomes. These cells also contained myelin fragments from the original internodes. Microtubules displayed unique relationships with cytoplasmic membranes and were seen to exist as regular 22 nm microtubules, as obliquely sectioned profiles or as incomplete, trough-shaped structures. Internodes devoid of myelin were common, and naked axons covered only by basal lamina appeared swollen and invariably contained an abundance of microtubules. Schwann cells lacking axons had multilobate nuclei and possessed complex arrays comprising smooth ER membranes and microtubules. In areas where microtubules were absent, these membranes compacted to form intracellular myelin. Intermediate filaments existed in lower numbers than normal within both axons and Schwann cells. Arrested mitoses were occasionally seen and it is speculated that together with the immobilization of the cell by the over-abundant polymerization of tubulin, incomplete mitosis was an underlying cause for the observed lack of remyelination over the 21-day period of study. These results suggest that perturbations in microtubule synthesis might dramatically affect Schwann cell behaviour and myelin proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01150269
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The anterior medullary velum and its involvement during autoimmune demyelination (1986)
    Springer
    Journal of neurocytology 15 (1986), S. 261-272 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The anterior medullary velum (AMV), a thin lamina of central white matter forming the roof of the IVth ventricle, has been analysed ultrastructurally in the normal guinea pig and in guinea pigs with chronic relapsing experimental allergic encephalomyelitis. In the latter condition, the AMV appeared to provide a route of access for haematogenous elements from the circulation into the ventricular space. The normal AMV consisted of fascicles of myelinated nerve fibres embedded in a layer of highly attenuated ependymal cells. Between the fascicles, the AMV was comprised merely of a layer of ependymal cytoplasm, in places about 0.5 μm thick. In contrast to ependymal cells from other levels of the neuraxis, in ependymal cells in the AMV, ciliary rootlets of the basal body apparatus were extraordinarily long, numerous and prominent. Their prominence might be related to a need for increased flexibility in this region of the ventricular system. Despite previous claims to the contrary, nerve cell bodies were present within the AMV as well as many synaptic complexes, unmyelinated axons, and supra- and subependymal axons believed to belong to the serotoninergic plexuses. During autoimmune demyelination, the meningeal space over the AMV became heavily infiltrated, inflammatory cells entered the nerve fibre bundles, myelin was destroyed and, perhaps related to disruption of the ependymal layer in places, haematogenous macrophages gained access to the ventricular surface of the AMV. Clinical relapses were accompanied by renewed inflammatory and demyelinative activity and further attenuation of the AMV with concomitant fibrous astrogliosis. Thus the AMV is described in detail for the first time at the ultrastructural level and is presented as a region vulnerable during periods of meningeal infiltration. The cytoarchitecture of the AMV might contribute to the genesis of demyelinated plaques around the IVth ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611662
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Microtubule-mitochondrial associations in regenerating axons after taxol intoxication (1987)
    Springer
    Journal of neurocytology 16 (1987), S. 461-468 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural examination of regenerating axons within rat sciatic nerve injected locally with the microtubule assembly-promoting compound, taxol, has revealed the frequent association of microtubules with axoplasmic organelles, in particular mitochondria. This was characterized by the prodigious accumulation of axonal microtubules, some of which became aligned to form multilayered channels within which axoplasmic organelles were sequestered. Between each layer of microtubules forming the walls of these channels, a 5 nm filament, believed to derive from microtubule side-arm material, was present. The findings suggest that these microtubule channels might play a role in mitochondrial traffic across the lesion area. Similar but much less elaborate associations within axons between microtubules and axoplasmic organelles, including mitochondria, have been described previously. Within regenerating axonal sprouts, intermediate filaments were found only at later timepoints when they commonly occurred within the microtubule channels. It is proposed that taxol impedes axonal regrowth at an early stage of cytoskeleton formation and that the present observations represent drug-induced exaggerations of a normal phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01668500
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Acute stages of batrachotoxin-induced neuropathy: a morphologic study of a sodium-channel toxin (1986)
    Springer
    Journal of neurocytology 15 (1986), S. 573-583 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The acute effects of batrachotoxin, a steroidal neurotoxin which opens the membrane sodium channel, were observed morphologically at various time points up to 3 h after injection into rat peroneal nerve. Three changes were found. First, there was massive swelling of the axon at the node of Ranvier accompanied by retraction of paranodal myelin. Second, a similar swelling of unmyelinated axons was seen. Third, extracellular fluid accumulated along the internode in the adaxonal space, the intraperiod line of myelin and, rarely, the external mesaxon, with concomitant shrinkage of the axon. The first two changes might be explained on the basis of massive shift of sodium through the batrachotoxin-modified sodium channel into the axon and subsequent osmotic shift of fluid. The reason for the third change is not clear but probably also has a ionic basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611858
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...