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  • 1
    Electronic Resource
    Electronic Resource
    Comparative pharmacokinetic study of adriamycin and 4'epi-adriamycin after their simultaneous intravenous administration (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 629-631 
    Details
    ISSN: 1432-1041
    Keywords: adriamycin ; epirubicin ; anthraquinone glycosides ; pharmacokinetics ; chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma pharmacokinetics of adriamycin and 4'epi-adriamycin have been studied in 6 patients with ovarian carcinoma after simultaneous intravenous administration of equal amounts of the two anthracyclines. A highly selective liquid chromatographic analytical method permitted quantification of plasma concentrations of the two drugs as well as their corresponding 13-hydroxy metabolites. The plasma concentrations of each drug followed a three-compartment open model, with great interindividual variation in the pharmacokinetic parameters. On average, the area under the plasma concentration time curve (AUC) and the maximum plasma concentration (Cmax) were 1.6- and 1.2-times larger for adriamycin than for 4'epi-adriamycin. 4'Epi-adriamycin was eliminated faster than adriamycin by 4 of the 6 patients, the average terminal half-life of the latter being 1.4-times longer. The plasma concentrations of the 13-hydroxy metabolites did not exceed 20 ng/ml. Their AUC values averaged 23% of those of the intact drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542426
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Urinary modified nucleosides as tumor markers in cancer of the urinary organs or female genital tract (1985)
    Springer
    Urological research 13 (1985), S. 213-218 
    Details
    ISSN: 1434-0879
    Keywords: Urinary modified nucleoside ; Cancer of the urinary organs ; Cancer of the female genital tract ; Highperformance liquid chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a sensitive and specific method involving high-performance liquid chromatography, urinary levels of four modified nucleosides — pseudouridine (Ψ), 1-methylinosine (m1I), 1-methyladenosine (m1A), and 1-methylguanosine (m1G)-were investigated before and after treatment in 31 patients with cancer of the urinary organs or the female genital tract. Before treatment m1I was the most frequently elevated nucleoside (77%). Pretreatment urinary levels of Ψ, m1I, and m1A in patients with stage 2–4 cancer of the female genital tract were significantly elevated compared to human healthy volunteers (p〈0.005). Compared with the other nucleosides, Ψ appeared to correlate more closely with the clinical outcome (progression or regression) of patients with cancer of the female genital tract. In the case of patients with cancer of the urinary organs, m1I followed the clinical outcome better than the other nucleosides measured. Therefore Ψ and m1I seem to be useful for monitoring genito-urinary cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261578
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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