ISSN:
1573-4943
Keywords:
conformational predictions
;
secondary structures of vitamin K-dependent proteins
;
conformation of factor IX
;
conformation of factor X
;
conformation of prothrombin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The secondary structures of bovine blood coagulation factors IX and X, as well as that of bovine prothrombin, were predicted on the basis of a computerized combination of the Chou-Fasman and Burgess algorithms. Refinements in the predictions were made after consideration of the content of various secondary structures, as determined by circular dichroism studies of these same proteins. The final turn assignments were in good agreement with those assigned with use of an algorithm involving pattern matching of β-turns in proteins of known structure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01024878
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