ISSN:
1435-232X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Studies of the possible relationship between malformations of the neuraxis and the human major histocompatibility complex have been contributive to the search for a human equivalent of the murine T/t complex. We conducted a population and family study in 34 Japanese couples together with their children with neural tube defects. HLA-DR homozygosity among the affected children was significantly increased as compared with that in controls. HLA-DR and DQ maternal-paternal sharing was also significantly higher than the controls. Significantly higher frequencies of A11 (father), B35 (mother) and A11 (affected children) were observed. These data support the hypothesis that a T/t-like complex in or near the HLA complex might be etiologically related to neural tube defects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01910288
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