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  • 1
    Electronic Resource
    Electronic Resource
    Effects of a new TRH analogue, YM-14673 on a passive avoidance test as a possible criterion of improvement in cognitive disturbance in rodents (1988)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 338 (1988), S. 262-267 
    Details
    ISSN: 1432-1912
    Keywords: TRH ; YM-14673 ; Passive avoidance ; Amnesia ; Scopolamine ; Anoxia ; Cerebral ischemia ; Cycloheximide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of a new TRH analogue, YM-14673 (Nα-[[(S)-4-oxo-2-azetidinyl carbonyl]-l-histidyl-L-prolinamide dihydrate) on cognitive disturbance of passive avoidance response were studied in rodents in comparison with those of TRH and CDP-choline. The latency for entering from the illuminated into the dark compartments was shortened in anoxia and scopolamine-treated rats, cycloheximidetreated mice and cerebral ischemic gerbils. The shortened latency in these models was prolonged by administration of both YM-14673 and TRH in doses without effect on spontaneous movement. YM-14673 was about 10 times more potent than TRH in ameliorating the cognitive disturbance, whereas CDP-choline showed no influence on the learning ability. These results suggest that YM-14673 and TRH possess facilitatory effects on cerebral function and that YM-14673 was distinct from CDP-choline in pharmacological profile.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173398
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of a new TRH analogue, YM-14673 on the central nervous system (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 336 (1987), S. 561-565 
    Details
    ISSN: 1432-1912
    Keywords: YM-14673 ; TRH ; Arousal action ; Models of head trauma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of a new TRH analogue, YM-14673 (Nα-[{(S)-4-oxo-2-azetidinyl}carbonyl]-L-histidyl-L-prolinamide dihydrate) on the central nervous system were compared with those of TRH. YM-14673 was 10–40 times more potent than TRH in antagonizing pentobarbital-induced sleep and hypothermia, and ethanol-induced hypothermia in mice. YM-14673 accelerated recovery from disturbed consciousness induced by concussive head trauma in mice and normalized the behavior and spontaneous EEG disturbed by electrolytic lesion of the hypothalamus in cats with 25 -100 times greater potency than that of TRH. In the tests on pentobarbital sleeping time and EEG disturbance, the cerebral activating activity of YM-14673 was 8 –36 times longer-lasting than that of TRH. These results indicate that YM-14673 possesses potent arousal effects on the central nervous system. The mode of action of YM-14673 was also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169314
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of plasma polymers from tetramethylsilane, octamethylcyclotetrasiloxane, and methyltrimethoxysilane (1987)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 25 (1987), S. 1737-1744 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The products in inductively coupled plasma excited in organosilicic compounds were studied on chemical structures by spectroscopic methods. Plasma-polymerized tetramethylsilane (PA) contains not only Si—CH3 groups but also Si—H groups on IR and 29Si-NMR analyses. 13C-NMR spectrum of PA reveals that the crosslinked structure of PA is mainly constructed of Ch2 and CH groups. Plasma-polymerized octamethyleyclotetrasiloxane (PD4) is composed of Si—CH3 and Si—O groups. 13C- and 29Si-NMR spectra of PD4 point out the highly preservation of the structural units similar to the monomer. These data of PD4 suggest that PD4 is formed from the ring-opening polymerization by cleavages of Si—O bonds. 13C-NMR spectrum of poly[methyltrimethoxysilane] (PT) indicates the existence of CH3—O groups, meanwhile its 29Si-NMR analysis concludes that PT is chiefly composed of the structural units similar to the monomer. The surface analyses by XPS of PA, PD4 and PT suggest that these organosilicic plasma polymers resemble their starting materials.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1987.080250703
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  • 4
    Electronic Resource
    Electronic Resource
    Plasma polymerization of mixed monomer gases (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 26 (1988), S. 1721-1731 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this paper, plasma polymerization of mixed monomer gases was studied. In the films, the elements derived from each monomer are contained, and they are distributed homogeneously at a certain depth. The films are made up by the copolymers in which both monomers are combined. The chemical compositions of the copolymers can be controlled by changing the proportions of the two monomer gases. The films having gradual compositional change toward depth can be prepared by using a mixture of two monomer gases and changing their proportions during the plasma polymerization. These copolymeric and gradient copolymeric films were formed on porous glass hollow fibers, and gas permeability of these composite membranes was measured. The gradient copolymerization methods are available for the preparation of the membranes for gas separation.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1988.080260704
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  • 5
    Electronic Resource
    Electronic Resource
    Plasma-polymerized membranes and gas permeability. IV (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 37 (1989), S. 2773-2779 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1989.070370926
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  • 6
    Electronic Resource
    Electronic Resource
    Plasma polymerized membranes and gas permeability. II (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 31 (1986), S. 1999-2006 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Thin films were deposited onto porous substrates by plasma polymerization using three kinds of organosilicic compounds, tetramethylsilane (TMS), hexamethyldisiloxane (M2), and octamethylcyclotetrasiloxane (D4). Those composite membranes showed different characteristics of gas permeability. When D4 was plasma-deposited onto a porous substrate, the composites membrane showed the highest oxygen permeability and the lowest oxygen-to-nitrogen permeability ratio. The composite membrane prepared from TMS showed the permeability characteristics opposite to the membrane obtained from D4. Infrared spectrum of the polymer from D4 resembles that of dimethylpolysiloxane. The plasma polymers from TMS and M2 showed different profiles in Si—O absorption bands in the range 1100-1000 cm-1 or in absorption bands of SiCH3 groups in the range 850-750 cm-1 from respective monomers. X-ray photoelectron spectroscopic observation indicated that all the plasma polymers contained more than two species of Si atom with different oxidation states. The greater part of Si atoms in plasma polymers took the same oxidation states in corresponding monomer. The gas permeability characteristics were closely related to the oxidation states of Si atom in the plasma polymers.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1986.070310704
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  • 7
    Electronic Resource
    Electronic Resource
    Plasma-polymerized membranes and gas permeability III (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 34 (1987), S. 2701-2711 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Plasma-polymerized films of hexamethyldisiloxane were deposited onto various porous substrates having different pore sizes, and the gas permeability of these composite membranes was studied. In each membrane, permselectivity between oxygen and nitrogen was found, but the oxygen permeation rate was different with each substance tested. The minimum thickness of the plasma-polymerized film needed to plug all pores and show permselectivity is about five times the pore radius of the porous substrate. The maximum oxygen permeation rates of the permselective composite membranes are approximately proportional to the effective areas for the gas permeation and inversely proportional to the pore sizes. The composite membranes show high oxygen permeation rates in cases using porous glass hollow fibers which have small pore sizes and large surface porosity as porous substrates. In cases using polysulfone hollow fibers which have high permselectivity, the composite membranes show much higher permeability ratios of oxygen-to-nitrogen than do those of the porous glass hollow fibers.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1987.070340807
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  • 8
    Electronic Resource
    Electronic Resource
    Spectroscopic study on chemical structure of plasma-polymerized hexamethyldisiloxane (1985)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 23 (1985), S. 615-622 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A plasma-polymerized material was produced from hexamethyldisiloxane vapor by a glow discharge polymerization technique. Spectroscopic interpretation of the chemical structure of the polymerized hexamethyldisiloxane was studied by spectroscopic means such as IR, XPS, and NMR. The plasma polymer was barely soluble in the usual organic solvents, although it contained a small amount of the monomer and its oligomers. The IR spectrum indicated that the polymer consisted of Si—CH3, Si—O, Si—CH2, and Si—H groups. The surface of the polymer was found to retain structural units similar to the monomer from the XPS measurement. On the other hand, the 13C and 29Si high-resolution, solid-state NMR measurements revealed that the plasma polymer was highly crosslinked with a variety of conformations and a number of O atoms surrounding a Si atom. Results from the XPS and NMR spectra suggested that the bulk of the polymer was more oxidized than the surface layer; Si atom was preferentially oxidized. A hypothetical chemical structure was proposed for the polymerized hexamethyl-disiloxane.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1985.170230303
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