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Comparative investigations on the effect of the phase-specific drug vincristine (VCR) on the proliferation kinetics of a solid experimental tumor (1983)

Lacroix, W. Féaux ; Klein, M.

Springer

Journal of cancer research and clinical oncology 106 (1983), S. 187-191

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ISSN: 1432-1335

Keywords: Tumor ; Cytostatic drug ; Proliferation kinetics ; Synchronization

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The aim of the present investigation was to compare the effects of repeated and single applications of vincristine (VCR) to a solid tumor in mice during the phase of tumor growth retardation 14 days after transplantation. Furthermore an attempt was made to induce synchronized tumor cell proliferation. Retardation of volume growth was found to be very much more pronounced after repeated application of VCR than after a single dose of this cytostatic drug. The intensity of the effect decreased within the tumor itself from the periphery to the centre. A synchronization of tumor cell prolifertion by flow out from the mitotic block or by a high simultaneous recruitment of previously noncycling tumor cells into the cell cycle could not be demonstrated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00402606

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Large displacement, transient analysis of space frames (1977)

Belytschko, T. ; Schwer, L. ; Klein, M. J.

Chichester [u.a.] : Wiley-Blackwell

International Journal for Numerical Methods in Engineering 11 (1977), S. 65-84

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ISSN: 0029-5981

Keywords: Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mathematics , Technology

Notes: A formulation is presented for the transient analysis of space frames in large displacement, small strain problems. For purposes of treating arbitrarily large rotations, node orientations are described by unit vectors and deformable elements are treated by a co-rotational (rigid-convected) description. Deformable elements may be connected either to nodes directly or through rigid bodies. The equations of motion are integrated by an explicit procedure. Sample results are presented on the snap-through of an arch-type structure and an idealization of a vehicle-barrier impact.

Additional Material: 8 Ill.