ISSN:
1432-1912
Keywords:
Halothane
;
Biotransformation
;
Phospholipids
;
Liver microsomal membranes
;
NMR-Spectroscopy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary N-trifluoroacetyl phosphatidyl ethanolamine was found as an intermediate of biotransformation of halothane after intense in vivo exposure of non-induced and phenobarbital induced rabbits. The metabolite has been identified in detergent treated liver microsomes by 31P-NMR-spectroscopy and in microsomal lipid extracts by 19F-NMR-and 1H-NMR-spectroscopy as well as by thin layer chromatography. The same exposure changed phospholipid composition of liver microsomal membranes: most prominent was a substantial decrease of the ratio of phosphatidyl ethanolamines to phosphatidyl cholines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00505492
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