ISSN:
1433-8491
Keywords:
Amitriptyline
;
Nortriptyline
;
Hydroxylated metabolites
;
Linear disposition
;
Interindividual differences
;
Pharmacological effects
;
Psychomotor tests
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In a companion paper we described the disposition of a 75 mg single dose of amitriptyline in normal volunteers who were phenotyped as extensive or poor metabolizers of debrisoquine and bufuralol, and had a four-fold range in the oral clearance of the antidepressant, 50 mg of amitriptyline was also administered to the same volunteers. This paper compares the results after both doses and suggests that the disposition of amitriptyline is linear even in subjects with a low oral clearance. There was no relation between the pharmacokinetic data and the intensity of sedation or of psychomotor impairment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00342785
Permalink
