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Aldosterone in vitro restores nephron Na−K-ATPase of distal segments from adrenalectomized rabbits (1980)

Horster, M. ; Schmid, H. ; Schmidt, U.

Springer

Pflügers Archiv 384 (1980), S. 203-206

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ISSN: 1432-2013

Keywords: Nephron epithelia ; Na−K-ATPase ; Aldosterone

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Aldosterone, when added in vitro to defined nephron segments, dissected from adrenalectomized rabbits, restores the depressed Na+−K+-ATPase activity in the thick ascending limb of the loop of Henle and in the cortical collecting tubule within 1 h of incubation. The direct effect is specific and, as demonstrated for the cortical collecting tubule, dose-dependent. The time course of aldosterone-mediated Na+−K+-ATPase activation is compatible with the conjecture of changes in the enzyme lipid environment.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00584554

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