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  • 1980-1984  (2)
  • 1970-1974
  • Benign prostatic hyperplasia  (1)
  • Computer package  (1)
  • 1
    ISSN: 1434-0879
    Keywords: Prolactin ; Prostate cancer ; Benign prostatic hyperplasia ; Androgen metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three experiments were performed to determine whether human prolactin (hPr) affects prostatic uptake and metabolism of testosterone (T). 1) Patients with prostatic cancer were infused twice with radio-labelled androgens, the first time with basal hPr, the second time with oral thyrotrophin-releasing hormone (TRH)-elevated hPr. In 5/7, significant increases in metabolic clearance of dihydrotestosterone (DHT) and in conversion of T to DHT accompanied increased hPr. 2) The incorporation of labelled T into minced benign prostatic hypertrophy (BPH) tissue from subjects with high (40 ng/ml) hPr was measured and was found to be more than twice the uptake into tissue from those with low hPr (6.5±1.9 ng/ml). 3) Uptake and metabolism in vivo of a bolus of 3H-T by BPH and carcinomatous prostates was measured and was far greater in subjects whose hPr was elevated by chlorpromazine than in untreated controls. It is concluded that prolactin increases prostatic uptake and metabolism of T. It is suggested that the best management of prostatic cancer should include depletion of prolactin as well as androgen.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Euphytica 33 (1984), S. 935-942 
    ISSN: 1573-5060
    Keywords: Computer package ; data base ; data manipulation ; field trials ; plant breeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A computer data base package, specifically designed to be used to store data collected from a plant breeding programme is described. The package will do many of the routine clerical operations involved in plant breeding, such as producing plot labels, field plans, genotype lists and data tabulations. It also has several statistical analysis routines, and routines which allow the user to examine and manipulate data. The package is user friendly since it was designed to be operated by plant breeders rather than computing specialists. Although it was written to handle data collected from a plant breeding programme, the package is flexible and could be used for a number of different applications.
    Type of Medium: Electronic Resource
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